دورية أكاديمية
أعرض في EDS

The longevity of Th2 humoral response induced by proteases natterins requires the participation of long-lasting innate-like B cells and plasma cells in spleen.

التفاصيل البيبلوغرافية
العنوان: The longevity of Th2 humoral response induced by proteases natterins requires the participation of long-lasting innate-like B cells and plasma cells in spleen.
المؤلفون: Komegae EN; Immunoregulation Unit, Special Laboratory of Applied Toxinology, Butantan Institute, São Paulo, Brazil., Grund LZ, Lopes-Ferreira M, Lima C
المصدر: PloS one [PLoS One] 2013 Jun 28; Vol. 8 (6), pp. e67135. Date of Electronic Publication: 2013 Jun 28 (Print Publication: 2013).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Immunity, Humoral*, B-Lymphocytes/*immunology , Fish Proteins/*immunology , Peptide Hydrolases/*immunology , Spleen/*immunology , Th2 Cells/*immunology, Animals ; Antibody Formation ; Bone Marrow Cells/immunology ; Cell Differentiation ; Cells, Cultured ; Fish Venoms/enzymology ; Immunity, Cellular ; Immunity, Innate ; Immunologic Memory ; Male ; Mice ; Mice, Inbred BALB C ; Proteolysis ; Spleen/cytology
مستخلص: The generation of long-lived antibody-secreting cells (ASC) and memory B cells are critical events for an effective vaccine and the choice of adjuvant can influence these processes. Various cellular and molecular mechanism involved in the protease action that determine Th2 responses have been identified. However, direct or indirect actions in the regulation of the induction, survival and longevity of ASC in differential compartments remain largely unknown. We investigated whether the proteolytic activity of proteins are determinant for the modulation of the memory immune response in mice, promoting the differentiation of memory B cells to terminally differentiated end stage cells. Here, we show that the proteolytic activity of Natterins, from the venom of Thalassophryne nattereri Brazilian fish, besides inducing a Th2 response with plasmatic titers of high-affinity antigen-specific IgE over extended periods is sufficient for the generation of signals that contribute to the formation of a survival niche in the spleen, essential for the longevity of the main subtype of ASC with B220(neg) phenotype.
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المشرفين على المادة: 0 (Fish Proteins)
0 (Fish Venoms)
EC 3.4.- (Peptide Hydrolases)
تواريخ الأحداث: Date Created: 20130711 Date Completed: 20140121 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3696013
DOI: 10.1371/journal.pone.0067135
PMID: 23840604
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0067135