دورية أكاديمية
Exogenous and endogenous antioxidants attenuate the lipid peroxidation in workers occupationally exposed to paints.
| العنوان: | Exogenous and endogenous antioxidants attenuate the lipid peroxidation in workers occupationally exposed to paints. |
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| المؤلفون: | Charão MF; Post-Graduate Programe in Pharmaceutical Sciences, Federal University of Rio Grande do Sul , Porto Alegre, RS , Brazil ., Moro AM, Valentini J, Brucker N, Bubols GB, Bulcão RP, Baierle M, Freitas FA, Nascimento SN, Barth A, Linden R, Saldiva PH, Garcia SC |
| المصدر: | Drug and chemical toxicology [Drug Chem Toxicol] 2014 Jan; Vol. 37 (1), pp. 69-75. Date of Electronic Publication: 2013 Jul 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Group Original Publication: New York, Dekker. |
| مواضيع طبية MeSH: | Occupational Exposure*, Antioxidants/*metabolism , Lipid Peroxidation/*drug effects , Paint/*analysis , Solvents/*toxicity, Adult ; Carotenoids/blood ; Chromatography, High Pressure Liquid ; Humans ; Lycopene ; Male ; Malondialdehyde/blood ; Paint/toxicity ; Regression Analysis ; Toluene/blood ; Vitamin A/blood ; alpha-Tocopherol/blood ; beta Carotene/blood |
| مستخلص: | Occupational exposure to organic solvents present in paints is responsible for an increased production of reactive species, thus enabling the development of several diseases. Besides, both exo- and endogenous antioxidant defense systems are necessary to avoid oxidative tissue damage. This study investigated possible protective effects of the exo- and endogenous antioxidants on oxidative damage in painters occupationally exposed to organic solvents (n = 42) and controls (n = 28). Retinol, lycopene and β-carotene were significantly lower in the exposed group. Despite the fact that blood toluene was below the biological exposure limits, malondialdehyde levels and antioxidant enzyme activities were increased, whereas reduced glutathione levels were decreased in painters, compared to nonexposed subjects. Moreover, multivariate regression models showed that reduced glutathione and carotenoids (mainly β-carotene) have the major influence on lipid peroxidation (LPO). The present work suggests that the exogenous antioxidants, such as carotenoids, could protect occupationally exposed subjects to xenobiotics from LPO. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Solvents) 01YAE03M7J (beta Carotene) 11103-57-4 (Vitamin A) 36-88-4 (Carotenoids) 3FPU23BG52 (Toluene) 4Y8F71G49Q (Malondialdehyde) H4N855PNZ1 (alpha-Tocopherol) SB0N2N0WV6 (Lycopene) |
| تواريخ الأحداث: | Date Created: 20130712 Date Completed: 20140714 Latest Revision: 20190116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3109/01480545.2013.806534 |
| PMID: | 23841515 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1525-6014 |
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| DOI: | 10.3109/01480545.2013.806534 |