دورية أكاديمية
Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes.
العنوان: | Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes. |
---|---|
المؤلفون: | Jia W; Department of Immunology, Duke University Medical Center Durham, NC, USA., He MX, McLeod IX, He YW |
المصدر: | Frontiers in immunology [Front Immunol] 2013 Jul 04; Vol. 4, pp. 179. Date of Electronic Publication: 2013 Jul 04 (Print Publication: 2013). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Print ISSN: 1664-3224 (Print) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مستخلص: | The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion of endoplasmic reticulum (ER) calcium stores and plays pivotal roles in T cell proliferation, cell survival, and apoptosis. In studying the roles of macroautophagy (hereafter referred to as autophagy) in T cell function, we found that a pathway for intracellular degradation, autophagy, regulates calcium signaling by developmentally maintaining the homeostasis of the ER. Using mouse genetic models with specific deletion of autophagy-related genes in T lymphocytes, we found that the calcium influx is defective and the calcium efflux is increased in autophagy-deficient T cells. The abnormal calcium flux is related to the expansion of the ER and higher calcium stores in the ER. Because of this, treatment with the ER sarco/ER Ca(2+)-ATPase pump inhibitor, thapsigargin, rescues the calcium influx defect in autophagy-deficient T cells. Therefore, autophagy regulates calcium mobilization in T lymphocytes through ER homeostasis. |
References: | J Immunol. 2006 Oct 15;177(8):5163-8. (PMID: 17015701) J Immunol. 2009 Apr 1;182(7):4046-55. (PMID: 19299702) Mol Microbiol. 2010 Feb;75(4):795-800. (PMID: 20487284) J Immunol. 2011 Feb 15;186(4):2201-9. (PMID: 21239722) J Immunol. 2011 May 1;186(9):5313-22. (PMID: 21421856) Mol Biol Cell. 2010 Jul 1;21(13):2257-69. (PMID: 20444978) PLoS One. 2012;7(12):e52347. (PMID: 23285000) J Mol Med (Berl). 2006 Mar;84(3):194-202. (PMID: 16501849) Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16258-63. (PMID: 22991461) Nature. 2007 Jun 28;447(7148):1121-5. (PMID: 17589504) Trends Cell Biol. 2012 Aug;22(8):397-406. (PMID: 22677446) Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211-6. (PMID: 19050071) Autophagy. 2013 Jun 1;9(6):942-4. (PMID: 23528926) Cell. 2008 Oct 3;135(1):110-22. (PMID: 18854159) Immunol Rev. 2012 Sep;249(1):195-204. (PMID: 22889223) Cell Death Differ. 2008 Sep;15(9):1385-95. (PMID: 18451870) J Immunol. 2010 Dec 15;185(12):7349-57. (PMID: 21059894) Oncotarget. 2012 Apr;3(4):435-49. (PMID: 22564965) Cell. 2010 May 14;141(4):656-67. (PMID: 20478256) J Biol Chem. 2006 Oct 6;281(40):30299-304. (PMID: 16901900) Cell Death Differ. 2012 Jan;19(1):144-52. (PMID: 21660048) Exp Cell Res. 1984 Nov;155(1):121-8. (PMID: 6489454) J Biol Chem. 2005 Jul 1;280(26):25291-7. (PMID: 15879595) Sci Rep. 2013;3:1055. (PMID: 23316280) Immunity. 2012 Jun 29;36(6):947-58. (PMID: 22658522) Annu Rev Cell Dev Biol. 2011;27:107-32. (PMID: 21801009) J Exp Med. 2007 Jan 22;204(1):25-31. (PMID: 17190837) Autophagy. 2006 Apr-Jun;2(2):135-7. (PMID: 16874086) Med Sci (Paris). 2006 Aug-Sep;22(8-9):677-8. (PMID: 16962030) J Clin Invest. 1967 Dec;46(12):1932-42. (PMID: 6073998) Front Immunol. 2012 Feb 21;3:22. (PMID: 22566906) Biochim Biophys Acta. 2009 Sep;1793(9):1404-12. (PMID: 19264099) Nat Cell Biol. 2010 Aug;12(8):747-57. (PMID: 20639872) PLoS One. 2010 Mar 16;5(3):e9715. (PMID: 20300520) Cell. 2011 Nov 11;147(4):728-41. (PMID: 22078875) Mol Cells. 2005 Dec 31;20(3):339-47. (PMID: 16404147) Trends Immunol. 2013 Jun;34(6):269-81. (PMID: 23474202) J Biol Chem. 2012 May 25;287(22):17914-29. (PMID: 22453917) Autophagy. 2012 Apr;8(4):445-544. (PMID: 22966490) J Immunol. 2011 Nov 15;187(10):5051-61. (PMID: 22021616) Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15;303(2):G189-98. (PMID: 22575222) Autophagy. 2009 Jul;5(5):649-62. (PMID: 19287211) Nat Immunol. 2008 Apr;9(4):432-43. (PMID: 18327260) Annu Rev Immunol. 2010;28:491-533. (PMID: 20307213) Cell. 2009 Mar 6;136(5):876-90. (PMID: 19249086) Autophagy. 2009 Jul;5(5):625-35. (PMID: 19276668) J Biol Chem. 2008 Jul 4;283(27):19112-8. (PMID: 18474606) Nature. 2013 Mar 21;495(7441):389-93. (PMID: 23455425) Nat Cell Biol. 2006 Jul;8(7):688-99. (PMID: 16799551) Nat Immunol. 2013 Mar;14(3):298-305. (PMID: 23354484) Curr Biol. 2005 Jul 12;15(13):1235-41. (PMID: 16005298) Cell Death Differ. 2007 May;14(5):1029-39. (PMID: 17256008) Mol Cell. 2007 Jan 26;25(2):193-205. (PMID: 17244528) EMBO J. 1999 Jul 15;18(14):3888-96. (PMID: 10406794) J Cell Biol. 2008 May 5;181(3):497-510. (PMID: 18443221) J Immunol. 2011 Feb 1;186(3):1564-74. (PMID: 21191072) Nat Cell Biol. 2010 Sep;12(9):814-22. (PMID: 20811353) Nat Cell Biol. 2009 Apr;11(4):468-76. (PMID: 19270693) Mol Biol Cell. 2008 Dec;19(12):5360-72. (PMID: 18843052) Immunity. 2007 Jul;27(1):11-21. (PMID: 17663981) Cell. 2013 Jan 17;152(1-2):290-303. (PMID: 23332761) Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002287. (PMID: 20519342) Nature. 2005 Oct 6;437(7060):902-5. (PMID: 16208375) Nature. 2011 Jan 20;469(7330):323-35. (PMID: 21248839) Mol Biol Cell. 2009 Apr;20(7):1992-2003. (PMID: 19225151) J Physiol. 2012 Sep 1;590(17):4157-67. (PMID: 22615435) PLoS Biol. 2006 Nov;4(12):e423. (PMID: 17132049) J Biol Chem. 2007 Jun 1;282(22):16232-43. (PMID: 17293345) Proc Natl Acad Sci U S A. 2012 May 29;109(22):8670-5. (PMID: 22592798) Nat Rev Immunol. 2007 Oct;7(10):767-77. (PMID: 17767194) Mol Cell Biol. 2006 Dec;26(24):9220-31. (PMID: 17030611) Exp Gerontol. 2004 May;39(5):789-800. (PMID: 15130673) Autophagy. 2010 Oct;6(7):912-21. (PMID: 20814235) Nat Cell Biol. 2009 Apr;11(4):385-96. (PMID: 19270696) Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6064-9. (PMID: 20231460) Autophagy. 2009 Oct;5(7):973-9. (PMID: 19597335) Proc Natl Acad Sci U S A. 2007 May 29;104(22):9301-6. (PMID: 17517596) Nature. 2006 Sep 14;443(7108):230-3. (PMID: 16921383) |
فهرسة مساهمة: | Keywords: ER homeostasis; ER-phagy; T lymphocytes; autophagy; calcium flux |
تواريخ الأحداث: | Date Created: 20130713 Date Completed: 20130712 Latest Revision: 20211021 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3701145 |
DOI: | 10.3389/fimmu.2013.00179 |
PMID: | 23847620 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-3224 |
---|---|
DOI: | 10.3389/fimmu.2013.00179 |