دورية أكاديمية
أعرض في EDS

Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes.

التفاصيل البيبلوغرافية
العنوان: Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes.
المؤلفون: Jia W; Department of Immunology, Duke University Medical Center Durham, NC, USA., He MX, McLeod IX, He YW
المصدر: Frontiers in immunology [Front Immunol] 2013 Jul 04; Vol. 4, pp. 179. Date of Electronic Publication: 2013 Jul 04 (Print Publication: 2013).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Print ISSN: 1664-3224 (Print) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion of endoplasmic reticulum (ER) calcium stores and plays pivotal roles in T cell proliferation, cell survival, and apoptosis. In studying the roles of macroautophagy (hereafter referred to as autophagy) in T cell function, we found that a pathway for intracellular degradation, autophagy, regulates calcium signaling by developmentally maintaining the homeostasis of the ER. Using mouse genetic models with specific deletion of autophagy-related genes in T lymphocytes, we found that the calcium influx is defective and the calcium efflux is increased in autophagy-deficient T cells. The abnormal calcium flux is related to the expansion of the ER and higher calcium stores in the ER. Because of this, treatment with the ER sarco/ER Ca(2+)-ATPase pump inhibitor, thapsigargin, rescues the calcium influx defect in autophagy-deficient T cells. Therefore, autophagy regulates calcium mobilization in T lymphocytes through ER homeostasis.
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فهرسة مساهمة: Keywords: ER homeostasis; ER-phagy; T lymphocytes; autophagy; calcium flux
تواريخ الأحداث: Date Created: 20130713 Date Completed: 20130712 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3701145
DOI: 10.3389/fimmu.2013.00179
PMID: 23847620
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2013.00179