دورية أكاديمية
Broadening the etiological discourse on Alzheimer's disease to include trauma and posttraumatic stress disorder as psychosocial risk factors.
| العنوان: | Broadening the etiological discourse on Alzheimer's disease to include trauma and posttraumatic stress disorder as psychosocial risk factors. |
|---|---|
| المؤلفون: | Burnes DP; Columbia University School of Social Work, 1255 Amsterdam Avenue, New York City, NY 10027, USA. db2735@columbia.edu, Burnette D |
| المصدر: | Journal of aging studies [J Aging Stud] 2013 Aug; Vol. 27 (3), pp. 218-24. Date of Electronic Publication: 2013 Apr 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Country of Publication: England NLM ID: 8916517 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-193X (Electronic) Linking ISSN: 08904065 NLM ISO Abbreviation: J Aging Stud Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003-> : Oxford : Pergamon Original Publication: Greenwich, Conn. : JAI Press, c1987- |
| مواضيع طبية MeSH: | Alzheimer Disease/*etiology , Stress Disorders, Post-Traumatic/*complications, Cognition ; Disease Progression ; Humans ; Models, Psychological ; Risk Factors ; Wounds and Injuries/complications |
| مستخلص: | Biomedical perspectives have long dominated research on the etiology and progression of Alzheimer's disease (AD); yet these approaches do not solely explain observed variations in individual AD trajectories. More robust biopsychosocial models regard the course of AD as a dialectical interplay of neuropathological and psychosocial influences. Drawing on this broader conceptualization, we conducted an extensive review of empirical and theoretical literature on the associations of trauma, posttraumatic stress disorder (PTSD) and AD to develop a working model that conceptualizes the role of psychosocial stressors and physiological mechanisms in the onset and course of AD. The proposed model suggests two pathways. In the first, previous life trauma acts as a risk factor for later-life onset of AD, either directly or mediated by PTSD or PTSD correlates. In the second, de novo AD experiential trauma is associated with accelerated cognitive decline, either directly or mediated through PTSD or PTSD correlates. Evidence synthesized in this paper indicates that previous life trauma and PTSD are strong candidates as psychosocial risk factors for AD and warrant further empirical scrutiny. Psychosocial and neurological-based intervention implications are discussed. A biopsychosocial approach has the capacity to enhance understanding of individual AD trajectories, moving the field toward 'person-centered' models of care. (Copyright © 2013 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer's disease; Dementia; Posttraumatic stress disorder; Risk factors; Trauma |
| تواريخ الأحداث: | Date Created: 20130716 Date Completed: 20131017 Latest Revision: 20130715 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/j.jaging.2013.03.002 |
| PMID: | 23849419 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-193X |
|---|---|
| DOI: | 10.1016/j.jaging.2013.03.002 |