دورية أكاديمية
أعرض في EDS

Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia.

التفاصيل البيبلوغرافية
العنوان: Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia.
المؤلفون: Papanikolaou X; Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Rosenbaum ER; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Tyler LN; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Sawyer J; 1] Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA [2] Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Heuck CJ; Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Barlogie B; Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Cottler-Fox M; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
المصدر: Leukemia [Leukemia] 2014 Apr; Vol. 28 (4), pp. 888-93. Date of Electronic Publication: 2013 Jul 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : London : Nature Publishing Group, Specialist Journals
Original Publication: [Baltimore, Md.] : Williams & Wilkins, [c1987-
مواضيع طبية MeSH: Cell Separation* , Hematopoietic Stem Cell Transplantation*/adverse effects , Platelet Count*, Hematopoietic Stem Cells/*cytology , Multiple Myeloma/*surgery , Myelodysplastic Syndromes/*etiology, Adult ; Aged ; Aged, 80 and over ; Female ; Hematopoietic Stem Cell Mobilization ; Humans ; Male ; Middle Aged ; Risk ; Transplantation, Autologous
مستخلص: Collection of hematopoietic progenitor cells (HPC) after previous autologous hematopoietic progenitor cell transplant (aHCT) was studied in 221 patients with multiple myeloma (MM). With a total of 333 collections, the median number of CD34+ cells collected was 4.7 × 10(6) CD34+ cells/kg, and 74% of the patients collected ≥ 2.5 × 10(6) CD34+ cells/kg. Among 26 variables examined, the strongest predictor for poor collection was a platelet count <100 × 10(6)/l before mobilization (P<0.001). A subsequent aHCT was performed in 154 of the 221 patients. Sole use of HPC procured after aHCT in 86 patients was associated with delayed platelet recovery (P<0.001) and linked to development of myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities (MDS-CA; P=0.027, odds ratio (OR) 10.34) and a tendency towards clinical MDS/acute myeloid leukemia (AML; P=0.091, OR 3.57). However, treatment-related mortality (P=0.766) and time to absolute neutrophil count recovery ≥0.5 × 10(9)/l (P=0.879) were similar to when a pre-aHCT graft was used. Indeed, adding HPC collected before any aHCT neutralized the risk of MDS-CA or MDS/AML. Therefore, we advise generous initial HPC collection to broaden the salvage armamentarium for patients with MM.
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معلومات مُعتمدة: P01 CA055819 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20130716 Date Completed: 20140616 Latest Revision: 20220316
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4050973
DOI: 10.1038/leu.2013.214
PMID: 23852547
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5551
DOI:10.1038/leu.2013.214