دورية أكاديمية
Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis.
| العنوان: | Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis. |
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| المؤلفون: | Van Herwijnen MJ; Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, the Netherlands., Van Der Zee R, Van Eden W, Broere F |
| المصدر: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2013 Aug; Vol. 29 (5), pp. 448-54. Date of Electronic Publication: 2013 Jul 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8508395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5157 (Electronic) Linking ISSN: 02656736 NLM ISO Abbreviation: Int J Hyperthermia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London ; Philadelphia : Taylor & Francis, c1985- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid/*therapy , Heat-Shock Proteins/*immunology , T-Lymphocytes, Regulatory/*immunology, Adoptive Transfer ; Animals ; Arthritis, Rheumatoid/immunology ; Humans ; Immune Tolerance ; Peptides/therapeutic use |
| مستخلص: | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by excessive immune responses resulting in inflammation of the joints. Although current therapies can be successful in dampening inflammation, a long-lived state of tolerance is seldom achieved. Therefore, novel therapies are needed that restore and maintain tolerance in patients with RA. Targeting regulatory T cells (Tregs) is a successful strategy to achieve tolerance, as was shown in studies performed in animal models and in human clinical trials. The antigen-specificity of Tregs is crucial for their effectiveness and allows for very specific targeting of these cells. However, which antigen is suitable for autoimmune diseases such as RA, for which the autoantigens are largely unknown? Heat shock proteins (HSPs) are ubiquitously expressed and can be up-regulated during inflammation. Additionally, HSPs, or HSP-derived peptides are immunogenic and can be recognised by a variety of immune cells, including Tregs. Therefore, this review highlights the potential of HSP-specific Tregs to control inflammatory immune responses. Targeting HSP-specific Tregs in RA can be achieved via the administration of HSPs (derived peptides), thereby controlling inflammatory responses. This makes HSPs attractive candidates for therapeutic intervention in chronic autoimmune diseases, with the ultimate goal of inducing long-lasting tolerance. |
| المشرفين على المادة: | 0 (Heat-Shock Proteins) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20130719 Date Completed: 20140220 Latest Revision: 20130801 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3109/02656736.2013.811546 |
| PMID: | 23863094 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1464-5157 |
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| DOI: | 10.3109/02656736.2013.811546 |