دورية أكاديمية
Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers.
| العنوان: | Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers. |
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| المؤلفون: | Brucker N; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Laboratory of Toxicology (LATOX), Department of Clinical Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Moro AM, Charão MF, Durgante J, Freitas F, Baierle M, Nascimento S, Gauer B, Bulcão RP, Bubols GB, Ferrari PD, Thiesen FV, Gioda A, Duarte MM, de Castro I, Saldiva PH, Garcia SC |
| المصدر: | The Science of the total environment [Sci Total Environ] 2013 Oct 01; Vol. 463-464, pp. 884-93. Date of Electronic Publication: 2013 Jul 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Automobile Driving*/statistics & numerical data, Air Pollution/*adverse effects , Inflammation/*chemically induced , Occupational Exposure/*analysis , Oxidative Stress/*drug effects, Biomarkers/blood ; Biomarkers/urine ; Brazil/epidemiology ; Carboxyhemoglobin/analysis ; Cardiovascular Diseases/chemically induced ; Creatinine/urine ; Humans ; Interleukin-1beta/blood ; Interleukin-1beta/urine ; Interleukin-6/blood ; Interleukin-6/urine ; Lipid Peroxidation/drug effects ; Male ; Middle Aged ; Pyrenes/urine ; Risk Factors ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/urine |
| مستخلص: | Exposure to environmental pollutants has been recognised as a risk factor for cardiovascular events. 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) from traffic-related air pollution. Experimental studies indicate that PAH exposure could be associated with inflammation and atherogenesis. Thus, the purpose of this study was to evaluate whether the biomarker of PAH exposure is associated with biomarkers of inflammation and oxidative stress and if these effects modulate the risk of developing cardiovascular diseases in workers exposed to air pollution. This study included 60 subjects, comprising 39 taxi drivers and 21 non-occupationally exposed persons. Environmental PM2.5 and benzo[a]pyrene (BaP) levels, in addition to biomarkers of exposure and oxidative damage, were determined. Inflammatory cytokines (IL-1β, IL-6, IL-10, TNF-α, IFN-γ and hs-CRP) and serum levels of oxidised LDL (ox-LDL), auto-antibodies (ox-LDL-Ab) and homocysteine (Hcy) were also evaluated. PM2.5 and BaP exhibited averages of 12.4±6.9 μg m(-3) and 1.0±0.6 ng m(-3), respectively. Urinary 1-OHP levels were increased in taxi drivers compared to the non-occupationally exposed subjects (p<0.05) and were positively correlated with pro-inflammatory cytokines and negatively correlated with antioxidants. Furthermore, taxi drivers had elevated pro-inflammatory cytokines, biomarkers of oxidative damage, and ox-LDL, ox-LDL-Ab and Hcy levels, although antioxidant enzymes were decreased compared to the non-occupationally exposed subjects (p<0.05). In summary, our findings indicate that taxi drivers showed major exposure to pollutants, such as PAHs, in relation to non-occupationally exposed subjects. This finding was associated with higher inflammatory biomarkers and Hcy, which represent important predictors for cardiovascular events. These data suggest a contribution of PAHs to cardiovascular diseases upon occupational exposure. (© 2013.) |
| فهرسة مساهمة: | Keywords: 1-hydroxypyrene; Inflammation; Occupational exposure; Oxidative stress; Taxi drivers |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Interleukin-1beta) 0 (Interleukin-6) 0 (Pyrenes) 0 (Tumor Necrosis Factor-alpha) 9061-29-4 (Carboxyhemoglobin) AYI8EX34EU (Creatinine) N2H6O5V707 (1-hydroxypyrene) |
| تواريخ الأحداث: | Date Created: 20130723 Date Completed: 20140414 Latest Revision: 20161125 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.scitotenv.2013.06.098 |
| PMID: | 23872245 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
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| DOI: | 10.1016/j.scitotenv.2013.06.098 |