دورية أكاديمية
Carbimazole-induced myositis in the treatment of Graves' disease: a complication in genetically susceptible individuals?
| العنوان: | Carbimazole-induced myositis in the treatment of Graves' disease: a complication in genetically susceptible individuals? |
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| المؤلفون: | Lim AY; Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608. adoree.lim.y.y@sgh.com.sg, Kek PC, Soh AW |
| المصدر: | Singapore medical journal [Singapore Med J] 2013 Jul; Vol. 54 (7), pp. e133-6. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer - Medknow Country of Publication: India NLM ID: 0404516 Publication Model: Print Cited Medium: Internet ISSN: 2737-5935 (Electronic) Linking ISSN: 00375675 NLM ISO Abbreviation: Singapore Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: July 2022- : [Mumbai] : Wolters Kluwer - Medknow Original Publication: Singapore, Singapore Medical Assn. |
| مواضيع طبية MeSH: | Antithyroid Agents/*adverse effects , Carbimazole/*adverse effects , Graves Disease/*drug therapy , Myositis/*chemically induced , Myositis/*genetics, Female ; Genetic Predisposition to Disease ; Humans ; Myositis/therapy ; Young Adult |
| مستخلص: | A 24-year-old Chinese woman with Graves' disease presented with myositis two months after treatment with carbimazole. The patient's myositis resolved with hydration and cessation of carbimazole. No other causes of myositis were found, and a change in the medication to propylthiouracil was uneventful. Review of the literature suggests a possible genetic susceptibility, as the majority of reported cases are Asian in origin, similar to patients who present with thyroid periodic paralysis. Changing the antithyroid drugs (ATDs) administered, decreasing the dose of pre-existing ATDs in the treatment regimen or addition of levothyroxine has been shown to result in clinical improvement of this complication. These observations suggest various mechanisms of carbimazole-induced myositis in the treatment of Graves' disease, including the direct effect of ATDs on myocytes, immune-related responses secondary to ATDs and rapid decrements in thyroid hormone with ensuing myositis. |
| المشرفين على المادة: | 0 (Antithyroid Agents) 8KQ660G60G (Carbimazole) |
| تواريخ الأحداث: | Date Created: 20130801 Date Completed: 20140326 Latest Revision: 20220310 |
| رمز التحديث: | 20240628 |
| DOI: | 10.11622/smedj.2013145 |
| PMID: | 23900475 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2737-5935 |
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| DOI: | 10.11622/smedj.2013145 |