دورية أكاديمية
Autologous skin substitute for hard-to-heal ulcers: retrospective analysis on safety, applicability, and efficacy in an outpatient and hospitalized setting.
| العنوان: | Autologous skin substitute for hard-to-heal ulcers: retrospective analysis on safety, applicability, and efficacy in an outpatient and hospitalized setting. |
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| المؤلفون: | Blok CS; Department of Dermatology, VU Medical Center, Amsterdam, The Netherlands., Vink L, de Boer EM, van Montfrans C, van den Hoogenband HM, Mooij MC, Gauw SA, Vloemans JA, Bruynzeel I, van Kraan A, Kuik J, Waaijman T, Scheper RJ, Gibbs S |
| المصدر: | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2013 Sep-Oct; Vol. 21 (5), pp. 667-76. Date of Electronic Publication: 2013 Aug 08. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: United States NLM ID: 9310939 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-475X (Electronic) Linking ISSN: 10671927 NLM ISO Abbreviation: Wound Repair Regen Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010-> : Malden, MA : Blackwell Science Original Publication: St. Louis, MO : Mosby, c1993- |
| مواضيع طبية MeSH: | Skin, Artificial* , Wound Healing*, Ambulatory Care/*statistics & numerical data , Hospitalization/*statistics & numerical data , Ulcer/*therapy, Adult ; Aged ; Aged, 80 and over ; Chronic Disease ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Netherlands/epidemiology ; Outpatients/statistics & numerical data ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Ulcer/epidemiology ; Ulcer/physiopathology |
| مستخلص: | Chronic ulcers ((arterio)venous, decubitus, or postoperative) have no tendency to heal within a period of at least 3 months despite optimal therapy according to internationally accepted guidelines. This retrospective study evaluates the safety and efficacy of an autologous, dermal-epidermal skin substitute (SS) for treating ulcers of various origins. Ulcers were treated within 7 Dutch centers over 5 years. Sixty-six ulcers (size: 0.75-150 cm²; duration: 0.25-32 years) with a follow-up time of 24 weeks after a single-skin substitute application were assessed. Wound-bed preparation consisted of vacuum-assisted-closure-therapy (5 days, hospitalized) or application of acellular dermis (5-7 days, outpatient). Time to heal, adverse events, and recurrence 1 year after complete healing were recorded. Complete ulcer healing occurred in 36 of 66 ulcers (55%) at 24 weeks. At that time point, a further 29% of ulcers showed decrease in ulcer size between 50 and 99%. No difference was observed between the hospitalized vs. outpatient treatment with complete healing. There were 32 of 36 healed ulcers that were available for follow-up 1 year after complete closure, of which 27 (84%) were still closed. Only two minor/moderate possibly related adverse events were recorded. This retrospective analysis shows that SS provides a safe and successful treatment for particularly chronic ulcers of various origins. (© 2013 by the Wound Healing Society.) |
| التعليقات: | Erratum in: Wound Repair Regen. 2013 Nov-Dec;21(6):909. |
| تواريخ الأحداث: | Date Created: 20130810 Date Completed: 20140519 Latest Revision: 20140715 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/wrr.12082 |
| PMID: | 23926998 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-475X |
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| DOI: | 10.1111/wrr.12082 |