دورية أكاديمية
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.
| العنوان: | Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. |
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| المؤلفون: | Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. rseder@mail.nih.gov, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJ, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja A, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BK, Ledgerwood JE, Graham BS, Hoffman SL |
| مؤلفون مشاركون: | VRC 312 Study Team |
| المصدر: | Science (New York, N.Y.) [Science] 2013 Sep 20; Vol. 341 (6152), pp. 1359-65. Date of Electronic Publication: 2013 Aug 08. |
| نوع المنشور: | Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Malaria Vaccines/*administration & dosage , Malaria Vaccines/*immunology , Malaria, Falciparum/*prevention & control , Plasmodium falciparum/*immunology, Administration, Intravenous ; Adult ; Animals ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Malaria Vaccines/adverse effects ; Male ; Mice ; Sporozoites/immunology ; T-Lymphocytes/immunology ; Vaccination/adverse effects ; Vaccination/methods |
| مستخلص: | Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine--composed of attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolerated when administered four to six times intravenously (IV) to 40 adults. Zero of six subjects receiving five doses and three of nine subjects receiving four doses of 1.35 × 10(5) PfSPZ Vaccine and five of six nonvaccinated controls developed malaria after controlled human malaria infection (P = 0.015 in the five-dose group and P = 0.028 for overall, both versus controls). PfSPZ-specific antibody and T cell responses were dose-dependent. These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards. |
| التعليقات: | Comment in: Science. 2013 Sep 20;341(6152):1352-3. (PMID: 24052298) |
| معلومات مُعتمدة: | 3R44AI055229-06S1 United States AI NIAID NIH HHS; 4R44AI055229-08 United States AI NIAID NIH HHS; 5R44AI058499-05 United States AI NIAID NIH HHS; N01-AI-40096 United States AI NIAID NIH HHS; United States Intramural NIH HHS; United States Howard Hughes Medical Institute |
| فهرسة مساهمة: | Investigator: C DiGiovanni; P Williams; N Luongo; J Mitchell; MB Florez; B Larkin; N Berkowitz; B Wilson; T Clarke; O Vasilenko; G Yamshchikov; S Sitar; L Stanford; I Pittman; RT Bailer; J Casazza; H Decederfelt; J Starling; EC Williams; A Lau; S Antonara; J Brocious; M Kemp; J Inglese; P Dranchak; EN Abot; S Reyes; H Ganeshan; M Belmonte; J Huang; A Belmonte; J Komisar; Y Abebe; Y Getachew; A Patil; S Matheny; K Nelson; J Overby; V Pich; Y Wen; R Fan; E Fomumbod; A Awe; C Chakiath; M King; MS Orozco; T Murshedkar; D Padilla; B Jiang; L Gao; N Kc; R Xu; M Adams; C Plowe; H Loblein; PZ Renehan; M Kunchai; L Diep |
| سلسلة جزيئية: | ClinicalTrials.gov NCT01441167 |
| المشرفين على المادة: | 0 (Cytokines) 0 (Malaria Vaccines) |
| تواريخ الأحداث: | Date Created: 20130810 Date Completed: 20131024 Latest Revision: 20150813 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1126/science.1241800 |
| PMID: | 23929949 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
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| DOI: | 10.1126/science.1241800 |