دورية أكاديمية
Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems.
العنوان: | Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems. |
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المؤلفون: | Le XT; Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan., Pham HT, Do PT, Fujiwara H, Tanaka K, Li F, Van Nguyen T, Nguyen KM, Matsumoto K |
المصدر: | Neurochemical research [Neurochem Res] 2013 Oct; Vol. 38 (10), pp. 2201-15. Date of Electronic Publication: 2013 Aug 15. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers Original Publication: New York, Plenum Press |
مواضيع طبية MeSH: | Bacopa/*chemistry , Memory Disorders/*drug therapy , Olfactory Bulb/*physiology , Plant Extracts/*therapeutic use, Acetylcholinesterase/metabolism ; Acoustic Stimulation ; Animals ; Choline O-Acetyltransferase/biosynthesis ; Choline O-Acetyltransferase/metabolism ; Fear ; Male ; Maze Learning/drug effects ; Mice ; Neuronal Plasticity/drug effects ; Phytotherapy ; Scopolamine/pharmacology ; Signal Transduction/drug effects |
مستخلص: | This study investigated the effects of alcoholic extract of Bacopa monnieri (L.) Wettst. (BM) on cognitive deficits using olfactory bulbectomized (OBX) mice and the underlying molecular mechanisms of its action. OBX mice were treated daily with BM (50 mg/kg, p.o.) or a reference drug, tacrine (2.5 mg/kg, i.p.), 1 week before and continuously 3 days after OBX. Cognitive performance of the animals was analyzed by the novel object recognition test, modified Y maze test, and fear conditioning test. Brain tissues of OBX animals were used for neurochemical and immunohistochemical studies. OBX impaired non-spatial short-term memory, spatial working memory, and long-term fair memory. BM administration ameliorated these memory disturbances. The effect of BM on short-term memory deficits was abolished by a muscarinic receptor antagonist, scopolamine. OBX downregulated phosphorylation of synaptic plasticity-related signaling proteins: NR1 subunit of N-methyl-D-aspartate receptor, glutamate receptor 1 (GluR1), and calmodulin-dependent kinase II but not cyclic AMP-responsive element binding protein (CREB), and reduced brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus. OBX also reduced choline acetyltransferase in the hippocampus and cholinergic neurons in the medial septum, and enlarged the size of lateral ventricle. BM administration reversed these OBX-induced neurochemical and histological alterations, except the decrease of GluR1 phosphorylation, and enhanced CREB phosphorylation. Moreover, BM treatment inhibited ex vivo activity of acetylcholinesterase in the brain. These results indicate that BM treatment ameliorates OBX-induced cognition dysfunction via a mechanism involving enhancement of synaptic plasticity-related signaling and BDNF transcription and protection of cholinergic systems from OBX-induced neuronal damage. |
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المشرفين على المادة: | 0 (Plant Extracts) DL48G20X8X (Scopolamine) EC 2.3.1.6 (Choline O-Acetyltransferase) EC 3.1.1.7 (Acetylcholinesterase) |
تواريخ الأحداث: | Date Created: 20130817 Date Completed: 20140328 Latest Revision: 20211021 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/s11064-013-1129-6 |
PMID: | 23949198 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-6903 |
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DOI: | 10.1007/s11064-013-1129-6 |