دورية أكاديمية
One dose of tranexamic acid is safe and effective in revision knee arthroplasty.
| العنوان: | One dose of tranexamic acid is safe and effective in revision knee arthroplasty. |
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| المؤلفون: | Smit KM; Division of Orthopaedic Surgery, Western University, London Health Sciences Centre, London, Ontario, Canada., Naudie DD, Ralley FE, Berta DM, Howard JL |
| المصدر: | The Journal of arthroplasty [J Arthroplasty] 2013 Sep; Vol. 28 (8 Suppl), pp. 112-5. Date of Electronic Publication: 2013 Aug 13. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor and Francis Country of Publication: United States NLM ID: 8703515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8406 (Electronic) Linking ISSN: 08835403 NLM ISO Abbreviation: J Arthroplasty Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New Brunswick, NJ : Taylor and Francis Original Publication: [New York, NY : Churchill Livingstone, c1986- |
| مواضيع طبية MeSH: | Arthroplasty, Replacement, Knee*, Blood Loss, Surgical/*prevention & control , Tranexamic Acid/*adverse effects , Tranexamic Acid/*therapeutic use, Aged ; Antifibrinolytic Agents/adverse effects ; Antifibrinolytic Agents/therapeutic use ; Blood Transfusion/statistics & numerical data ; Cohort Studies ; Dose-Response Relationship, Drug ; Female ; Hemoglobins/metabolism ; Humans ; Male ; Middle Aged ; Reoperation ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42±16g/L vs 38±15g/L, P=0.005), transfusion rates (30.3% vs 16.7%, P=0.001) and average amount transfused (1.1±1.9units vs 0.5±1.1units, P=0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA. (© 2013.) |
| فهرسة مساهمة: | Keywords: blood loss; revision knee arthroplasty; tranexamic acid |
| المشرفين على المادة: | 0 (Antifibrinolytic Agents) 0 (Hemoglobins) 6T84R30KC1 (Tranexamic Acid) |
| تواريخ الأحداث: | Date Created: 20130820 Date Completed: 20140529 Latest Revision: 20220331 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.arth.2013.05.036 |
| PMID: | 23953962 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-8406 |
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| DOI: | 10.1016/j.arth.2013.05.036 |