دورية أكاديمية
Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound.
| العنوان: | Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound. |
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| المؤلفون: | Koga S; Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Ikeda S, Yoshida T, Nakata T, Takeno M, Masuda N, Koide Y, Kawano H, Maemura K |
| المصدر: | JACC. Cardiovascular interventions [JACC Cardiovasc Interv] 2013 Sep; Vol. 6 (9), pp. 945-54. Date of Electronic Publication: 2013 Aug 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101467004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7605 (Electronic) Linking ISSN: 19368798 NLM ISO Abbreviation: JACC Cardiovasc Interv Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier |
| مواضيع طبية MeSH: | Plaque, Atherosclerotic* , Tomography, Optical Coherence* , Ultrasonography, Interventional*, C-Reactive Protein/*analysis , Coronary Artery Disease/*diagnosis , Coronary Vessels/*diagnostic imaging , Coronary Vessels/*pathology , Inflammation Mediators/*blood , Serum Amyloid P-Component/*analysis, Aged ; Biomarkers/blood ; Case-Control Studies ; Chi-Square Distribution ; Coronary Angiography ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/pathology ; Female ; Fibrosis ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Up-Regulation |
| مستخلص: | Objectives: This study sought to determine whether systemic levels of pentraxin 3 (PTX3), a novel inflammatory marker, are associated with thin-cap fibroatheroma (TCFA). Background: Biomarkers predicting the presence of TCFA in vivo have not been established. Methods: We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, n = 28) with de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. We defined TCFA as lipid-rich plaque with a fibrous cap <65 μm thick. Systemic levels of PTX3 were compared between patients with and without TCFA. Results: Thirty-eight and 37 patients with and without TCFA, respectively, were identified. Levels of PTX3 were significantly higher in patients with than in those without TCFA (p < 0.001) and correlated inversely with fibrous cap thickness (r = -0.71, p = 0.001) and positively with the remodeling index (r = 0.25, p = 0.037). Multivariate logistic regression analysis showed that a higher PTX3 level was the most powerful predictor of TCFA (odds ratio: 3.26, 95% confidence interval: 1.75 to 6.05, p < 0.001). Receiver-operating characteristic curve analysis showed that >3.24 ng/ml of PTX3 could predict TCFA with 84% sensitivity and 86% specificity. Conclusions: Higher levels of systemic PTX3 are associated with TCFA. Systemic PTX3 levels comprise a useful inflammatory marker that reflects coronary plaque vulnerability. (Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ACS; AMI; C-reactive protein; CRP; CSA; EEM; IVUS; OCT; P+M; PTX3; SAP; TCFA; UAP; acute coronary syndromes; acute myocardial infarction; cross-sectional area; external elastic membrane; high-sensitivity C-reaction protein; hs-CRP; intravascular ultrasound; optical coherence tomography; pentraxin 3; plaque plus media; stable angina pectoris; thin-cap fibroatheroma; unstable angina pectoris; vulnerable plaque |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Inflammation Mediators) 0 (Serum Amyloid P-Component) 148591-49-5 (PTX3 protein) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20130820 Date Completed: 20140519 Latest Revision: 20220408 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jcin.2013.04.024 |
| PMID: | 23954061 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1876-7605 |
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| DOI: | 10.1016/j.jcin.2013.04.024 |