دورية أكاديمية
Non Protease Inhibitor-Based Highly Active Antiretroviral Therapy (HAART) improves micromineral status in HIV positive Nigerians.
| العنوان: | Non Protease Inhibitor-Based Highly Active Antiretroviral Therapy (HAART) improves micromineral status in HIV positive Nigerians. |
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| المؤلفون: | Okwara EC; drokwarachidiebere@yahoo.com., Meludu SC, Okwara JE, Enwere OO, Diwe KC, Amah UK, Ezeugwunne IP, Okwara EI |
| المصدر: | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria [Niger J Physiol Sci] 2013 Jun 30; Vol. 28 (1), pp. 105-7. Date of Electronic Publication: 2013 Jun 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physiological Society of Nigeria Country of Publication: Nigeria NLM ID: 8811109 Publication Model: Electronic Cited Medium: Internet ISSN: 0794-859X (Print) Linking ISSN: 0794859X NLM ISO Abbreviation: Niger J Physiol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Benin City, Nigeria : Physiological Society of Nigeria |
| مواضيع طبية MeSH: | Antiretroviral Therapy, Highly Active* , HIV Infections*, Humans ; Prospective Studies ; Protease Inhibitors ; Selenium |
| مستخلص: | Introduction of highly active antiretroviral therapy (HAART) has improved the prognosis of human immunodeficiency virus (HIV) infection. The social burden of HIV infection in Nigeria is well appreciated, but the consequences of this infection and HAART on micro mineral status are unknown in Nigeria. We evaluated these effects in Orlu, Imo State, Nigeria. This prospective study involved 51 adult HIV positive patients (18-56 years). Serum selenium, magnesium and zinc were measured using atomic absorption spectrophotometry before and after 6 months on HAART. Results are presented as means while comparison of variables was done using paired t-tests. P-value < 0.05 was considered significant. Selenium, magnesium and zinc levels in the participants before HAART were 0.23±0.08 mmol/L, 104.61±24.16 mmol/L and 9.04±1.26 mmol/L respectively. Mineral levels 6 months after HAART were 0.25±0.08 mmol/L, 115.57±27.98 mmol/L and 9.41±1.23 mmol/L respectively. Selenium and magnesium levels significantly increased after 6 months on HAART (p < 0.05) while zinc level did not increase significantly (p> 0.05). HAART improved selenium and magnesium status of HIV patients but their zinc status remained the same. |
| المشرفين على المادة: | 0 (Protease Inhibitors) H6241UJ22B (Selenium) |
| تواريخ الأحداث: | Date Created: 20130820 Date Completed: 20160422 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| PMID: | 23955416 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0794-859X |
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