دورية أكاديمية
Salvage intracerebrospinal fluid thiotepa in breast cancer-related leptomeningeal metastases: a retrospective case series.
| العنوان: | Salvage intracerebrospinal fluid thiotepa in breast cancer-related leptomeningeal metastases: a retrospective case series. |
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| المؤلفون: | Le Rhun E; aBreast Unit, Department of Medical Oncology Departments of bClinical Pharmacy cRadiology dPathology, Oscar Lambret Center eNeuro-oncology, Department of Neurosurgery fDepartment of Neurosurgery, Roger Salengro Hospital, University Hospital gDepartment of Biostatistics, University Hospital hUniversity of Lille Nord de France, Lille Departments of iRadiation Oncology jNeuro-oncology, Pitié-Salpétrière Hospital, Paris, France kDepartment of Neurology, Fred Hutchinson Cancer Research Center lNeuro-oncology Clinic, University of Washington, Seattle, Washington, USA., Taillibert S, Devos P, Zairi F, Turpin A, Rodrigues I, Cazin JL, Pierret MF, André C, Dubois F, Bonneterre J, Chamberlain MC |
| المصدر: | Anti-cancer drugs [Anticancer Drugs] 2013 Nov; Vol. 24 (10), pp. 1093-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100823 Publication Model: Print Cited Medium: Internet ISSN: 1473-5741 (Electronic) Linking ISSN: 09594973 NLM ISO Abbreviation: Anticancer Drugs Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Lippincott Williams & Wilkins Original Publication: Oxford, UK : Rapid Communications of Oxford, [1990- |
| مواضيع طبية MeSH: | Meningeal Neoplasms*/cerebrospinal fluid , Meningeal Neoplasms*/drug therapy , Meningeal Neoplasms*/secondary , Salvage Therapy*, Antineoplastic Agents, Alkylating/*therapeutic use , Breast Neoplasms/*drug therapy , Thiotepa/*therapeutic use, Adult ; Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/cerebrospinal fluid ; Breast Neoplasms/cerebrospinal fluid ; Breast Neoplasms/pathology ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Retrospective Studies ; Spinal Puncture ; Thiotepa/administration & dosage ; Thiotepa/cerebrospinal fluid |
| مستخلص: | There is currently a paucity of data on salvage intracerebrospinal fluid (intra-CSF) chemotherapy in leptomeningeal metastases (LM). This report is a single-institution experience with salvage treatment in patients with breast cancer (BC) and LM. This retrospective cohort describes 24 consecutive patients with BC selected for a second-line of treatment for LM. The first line of LM treatment consisted of intra-CSF liposomal cytarabine in all patients combined with systemic therapy in 18 cases and radiotherapy in four cases. Second-line (salvage) treatment utilized intra-CSF thiotepa in all and systemic chemotherapy in nine patients. No patient received CNS-directed radiotherapy. The median Eastern Cooperative Oncology Group performance status at initiation of intra-CSF thiotepa treatment was 3 (range 1-4). The median progression-free survival and median survival following intra-CSF thiotepa was 3.1 months (range 3 days-2 years) and 4.0 months (range 6 days-2.5 years), respectively. The median overall survival from LM diagnosis was 9.5 months (range 1.3 months-2.7 years). No grade 3 or higher toxicity was observed. Recognizing the limits of a retrospective study, intra-CSF thiotepa has an acceptable toxicity profile and appears to be a reasonable option for selected BC patients. |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Alkylating) 905Z5W3GKH (Thiotepa) |
| تواريخ الأحداث: | Date Created: 20130822 Date Completed: 20140505 Latest Revision: 20130930 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/CAD.0000000000000010 |
| PMID: | 23962903 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5741 |
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| DOI: | 10.1097/CAD.0000000000000010 |