دورية أكاديمية
أعرض في EDS

Methionine and methionine sulfoxide alter parameters of oxidative stress in the liver of young rats: in vitro and in vivo studies.

التفاصيل البيبلوغرافية
العنوان: Methionine and methionine sulfoxide alter parameters of oxidative stress in the liver of young rats: in vitro and in vivo studies.
المؤلفون: Costa MZ; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n Capão do Leão, Pelotas, RS, 96010-900, Brazil., da Silva TM, Flores NP, Schmitz F, da Silva Scherer EB, Viau CM, Saffi J, Barschak AG, de Souza Wyse AT, Spanevello RM, Stefanello FM
المصدر: Molecular and cellular biochemistry [Mol Cell Biochem] 2013 Dec; Vol. 384 (1-2), pp. 21-8. Date of Electronic Publication: 2013 Aug 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: The Hague, Dr. W. Junk B. V. Publishers.
مواضيع طبية MeSH: Catalase/*metabolism , Liver/*metabolism , Methionine/*analogs & derivatives , Methionine/*metabolism, Amino Acid Metabolism, Inborn Errors/metabolism ; Amino Acid Metabolism, Inborn Errors/pathology ; Animals ; Fluoresceins/metabolism ; Glycine N-Methyltransferase/deficiency ; Glycine N-Methyltransferase/metabolism ; Liver/pathology ; Male ; Oxidative Stress ; Rats ; Rats, Wistar ; Reactive Oxygen Species/pharmacology ; Superoxide Dismutase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism
مستخلص: It has been shown that elevation of plasma methionine (Met) and its metabolites may occur in several genetic abnormalities. In this study we investigated the in vitro and in vivo effects of the Met and methionine sulfoxide (MetO) on oxidative stress parameters in the liver of rats. For in vitro studies, liver homogenates were incubated with Met, MetO, and Mix (Met + MetO). For in vivo studies, the animals were divided into groups: saline, Met 0.4 g/kg, MetO 0.1 g/kg, and Met 0.4 g/kg + MetO 0.1 g/kg. The animals were euthanized 1 and 3 h after injection. In vitro results showed that Met 1 and 2 mM and Mix increased catalase (CAT) activity. Superoxide dismutase (SOD) was enhanced by Met 1 and 2 mM, MetO 0.5 mM, and Mix. Dichlorofluorescein oxidation was increased by Met 1 mM and Mix. In vivo results showed that Met, MetO, and Mix decreased TBARS levels at 1 h. Total thiol content decreased 1 h after and increased 3 h after MetO and Met plus MetO administrations. Carbonyl content was enhanced by Met and was reduced by MetO 1 h after administration. Met, MetO and Met plus MetO decreased CAT activity 1 and 3 h after administration. Furthermore, only MetO increased SOD activity. In addition, Met, MetO, and Mix decreased dichlorofluorescein oxidation at 1 and 3 h. Our data indicate that Met/MetO in vivo and in vitro modify liver homeostasis by altering the redox cellular state. However, the hepatic changes caused by these compounds suggest a short-time adaptation of this tissue.
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المشرفين على المادة: 0 (Fluoresceins)
0 (Reactive Oxygen Species)
0 (Thiobarbituric Acid Reactive Substances)
56NQM5UZT1 (2',7'-dichlorofluorescein)
AE28F7PNPL (Methionine)
EC 1.11.1.6 (Catalase)
EC 1.15.1.1 (Superoxide Dismutase)
EC 2.1.1.20 (Glycine N-Methyltransferase)
XN1XVI4B2C (methionine sulfoxide)
SCR Disease Name: Hypermethioninemia
تواريخ الأحداث: Date Created: 20130822 Date Completed: 20140930 Latest Revision: 20211021
رمز التحديث: 20231215
DOI: 10.1007/s11010-013-1777-5
PMID: 23963990
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-4919
DOI:10.1007/s11010-013-1777-5