دورية أكاديمية
Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline.
| العنوان: | Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline. |
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| المؤلفون: | Rentala S; Department of Biotechnology, GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam - 530 045, INDIA., Konada S, Chintala R, Mangamoori LN, Upadhyayula SM, Dhurjeti SM |
| المصدر: | Bioinformation [Bioinformation] 2013 Aug 07; Vol. 9 (14), pp. 721-4. Date of Electronic Publication: 2013 Aug 07 (Print Publication: 2013). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Biomedical Informatics Pub. Group Country of Publication: Singapore NLM ID: 101258255 Publication Model: eCollection Cited Medium: Print ISSN: 0973-2063 (Print) Linking ISSN: 09732063 NLM ISO Abbreviation: Bioinformation Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Singapore] : Biomedical Informatics Pub. Group, 2005- |
| مستخلص: | Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment. |
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| فهرسة مساهمة: | Keywords: Anti-oxidants; Cataract formation; Docking scores; Oxidative stress; gamma-D-crystallin |
| تواريخ الأحداث: | Date Created: 20130827 Date Completed: 20130826 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3746095 |
| DOI: | 10.6026/97320630009721 |
| PMID: | 23976828 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0973-2063 |
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| DOI: | 10.6026/97320630009721 |