دورية أكاديمية
أعرض في EDS

Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death.

التفاصيل البيبلوغرافية
العنوان: Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death.
المؤلفون: Mussil B; Molecular Retrovirology Unit, Institut Pasteur, Paris, France., Suspène R, Aynaud MM, Gauvrit A, Vartanian JP, Wain-Hobson S
المصدر: PloS one [PLoS One] 2013 Aug 20; Vol. 8 (8), pp. e73641. Date of Electronic Publication: 2013 Aug 20 (Print Publication: 2013).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: DNA Breaks, Double-Stranded* , Stress, Physiological*, Cell Nucleus/*metabolism , Cytidine Deaminase/*metabolism , Proteins/*metabolism, Base Sequence ; CD4-Positive T-Lymphocytes/immunology ; Cell Cycle Checkpoints ; Cell Death ; Cytidine Deaminase/genetics ; HeLa Cells ; Histones/metabolism ; Humans ; Lymphocyte Activation ; Molecular Sequence Data ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Transport ; Proteins/genetics ; RNA Editing/genetics ; Signal Transduction/genetics ; Uracil-DNA Glycosidase/metabolism
مستخلص: Human APOBEC3 enzymes deaminate single stranded DNA. At least five can deaminate mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. However, only one, APOBEC3A, can hypermutate genomic DNA. We analysed the distribution and function of the two APOBEC3A isoforms p1 and p2 in transfected cell lines. Both can translocate to the nucleus and hypermutate CMYC DNA and induce DNA double strand breaks as visualized by the detection of ©H2AX or Chk2. APOBEC3A induced G1 phase cell cycle arrest and triggered several members of the intrinsic apoptosis pathway. Activation of purified human CD4+ T lymphocytes with PHA, IL2 and interferon α resulted in C->T hypermutation of genomic DNA and double stranded breaks suggesting a role for APOBEC3A in pro-inflammatory conditions. As chronic inflammation underlies many diseases including numerous cancers, it is possible that APOBEC3A induction may generate many of the lesions typical of a cancer genome.
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المشرفين على المادة: 0 (H2AX protein, human)
0 (Histones)
0 (Protein Isoforms)
0 (Proteins)
EC 3.2.2.- (Uracil-DNA Glycosidase)
EC 3.5.4.- (AICDA (activation-induced cytidine deaminase))
EC 3.5.4.5 (APOBEC3A protein, human)
EC 3.5.4.5 (Cytidine Deaminase)
تواريخ الأحداث: Date Created: 20130827 Date Completed: 20150115 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3748023
DOI: 10.1371/journal.pone.0073641
PMID: 23977391
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0073641