دورية أكاديمية
Antiparasitic antibodies occur with similar frequency in patients with clinically established multiple sclerosis with or without oligoclonal bands in the cerebrospinal fluid.
| العنوان: | Antiparasitic antibodies occur with similar frequency in patients with clinically established multiple sclerosis with or without oligoclonal bands in the cerebrospinal fluid. |
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| المؤلفون: | Fonseca-Papavero FC; Laboratório de Investigação Médica em Neurologia, FM, USP, São Paulo SP, Brazil. fabianacruz@lim15.fm.usp.br, Callegaro D, Gama PD, Livramento JA, Vaz AJ, Machado Ldos R |
| المصدر: | Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2013 Aug; Vol. 71 (8), pp. 512-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 0125444 Publication Model: Print Cited Medium: Internet ISSN: 1678-4227 (Electronic) Linking ISSN: 0004282X NLM ISO Abbreviation: Arq Neuropsiquiatr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [Stuttgart] : Thieme Original Publication: São Paulo. |
| مواضيع طبية MeSH: | Antibodies, Helminth/*blood , Antigens, Helminth/*blood , Multiple Sclerosis/*cerebrospinal fluid , Oligoclonal Bands/*cerebrospinal fluid , Taenia solium/*immunology, Animals ; Antibodies, Helminth/chemistry ; Electrophoresis, Polyacrylamide Gel ; Humans ; Molecular Weight |
| مستخلص: | Unlabelled: The "hygiene hypothesis" postulates an inverse relationship between the prevalence of parasitic infections and the frequency of multiple sclerosis (MS). Objective: It was to study whether antibodies against parasites could be demonstrated more frequently in blood serum from MS patients with oligoclonal bands (OCB) than from MS patients without OCB. Methods: We studied serum samples from 164 patients who had previously been analyzed to investigate OCB. Parasitic antibodies were studied through unidimensional electrophoresis of proteins on polyacrylamide gel against Taenia antigens, searching for antiparasitic specific low molecular weight antibodies and also for antiparasitic nonspecific high molecular weight antibodies. Results: Two of the 103 patients with no evidence of OCB had antibodies of low molecular weight and 59 of them had antibodies of high molecular weight. Of the 61 patients with evidence of OCB, one showed antibodies of low molecular weight and 16 showed antibodies of high molecular weight. Conclusion: Antiparasitic antibodies are detected with similar frequency in MS patients with OCB and in MS patients without OCB. |
| المشرفين على المادة: | 0 (Antibodies, Helminth) 0 (Antigens, Helminth) 0 (Oligoclonal Bands) |
| تواريخ الأحداث: | Date Created: 20130829 Date Completed: 20140206 Latest Revision: 20140731 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1590/0004-282X20130079 |
| PMID: | 23982007 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-4227 |
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| DOI: | 10.1590/0004-282X20130079 |