دورية أكاديمية
Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminata Teles Freire leaves on experimental ulcer models.
| العنوان: | Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminata Teles Freire leaves on experimental ulcer models. |
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| المؤلفون: | Viana AF; Medicinal Plants Research Center, Federal University of Piauí, Teresina, Brazil., Fernandes HB, Silva FV, Oliveira IS, Freitas FF, Machado FD, Costa CL, Arcanjo DD, Chaves MH, Oliveira FA, Oliveira RC |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2013 Oct 28; Vol. 150 (1), pp. 316-23. Date of Electronic Publication: 2013 Sep 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Fabaceae*, Plant Extracts/*therapeutic use , Protective Agents/*therapeutic use , Stomach Ulcer/*drug therapy, Animals ; Catalase/metabolism ; Disease Models, Animal ; Female ; KATP Channels/antagonists & inhibitors ; KATP Channels/metabolism ; Male ; Mice ; Nitric Oxide/metabolism ; Phytotherapy ; Plant Extracts/pharmacology ; Plant Leaves ; Protective Agents/pharmacology ; Rats ; Rats, Wistar ; Stomach/pathology ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology |
| مستخلص: | Ethnopharmacological Relevance: Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae-Caesalpinioideae), popularly known in Brazil as "caneleiro", is widely used in folk medicine against gastrointestinal diseases. In previous studies, the ethanol extract of leaves from Cenostigma macrophyllum Tul. var. acuminata Teles Freire had shown antinociceptive, anti-inflammatory, antibacterial, antioxidant and antiulcerogenic activities. Aim of the Study: The aim of this study was to assess the gastroprotective effect of the hydroalcoholic fraction of leaves of Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Cm-FHA), as well as to elucidate the possible underlying mechanisms of action. Materials and Methods: Mice were used for the evaluation of the acute toxicity, and mice and rats to study the gastroprotective activity. The potential gastroprotective of Cm-FHA was assessed on different gastric ulcer models in rodents, such as absolute ethanol, HCl/ethanol, ischemia-reperfusion, cold restraint stress and indomethacin. The participation of prostaglandins, NO-synthase pathway and ATP-sensitive potassium channels (KATP) in gastroprotective activity of Cm-FHA were evaluated after treatment with a cyclooxygenase inhibitor (indomethacin), a NO-synthase inhibitor (L-NAME) and a KATP channel blocker (glibenclamide 5mg/kg), respectively. Likewise, the catalase activity was determinated in order to assess the possible participation of antioxidant mechanisms. Results: No signs of acute toxicity was observed after oral acute administration of Cm-FHA, considering the analyzed parameters. Likewise, Cm-FHA promoted a protective effect against gastric ulcers induced by absolute ethanol (lesion inhibition by 40% at both 100 and 200mg/kg), HCl/ethanol (lesion inhibition by 50 or 48% at 100 or 200mg/kg, respectively), ischemia-reperfusion (lesion inhibition by 49 or 90% at 100 or 200mg/kg, respectively) and cold restraint stress (lesion inhibition by 63 or 76% at 100 or 200mg/kg, respectively), as well as a increase of catalase activity was observed. Otherwise, Cm-FHA was not able to protect gastric mucosa against indomethacin-induced lesions. Nitric oxide release, the of KATP channels opening and antioxidant activity are the possibly involved in the Cm-FHA-induced gastroprotective activity. Conclusion: This study corroborates the folk medicine use of Cenostigma macrophyllum for treatment of gastric ulcers, as well as reinforces this species as a valuable source of promising natural drugs with gastroprotective activity. (© 2013 Elsevier Ireland Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cenostigma macrophyllum; Gastroprotection; Leguminosae |
| المشرفين على المادة: | 0 (KATP Channels) 0 (Plant Extracts) 0 (Protective Agents) 31C4KY9ESH (Nitric Oxide) EC 1.11.1.6 (Catalase) |
| تواريخ الأحداث: | Date Created: 20130917 Date Completed: 20140519 Latest Revision: 20131011 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jep.2013.08.047 |
| PMID: | 24035848 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2013.08.047 |