دورية أكاديمية
أعرض في EDS

Genes contributing to subcortical volumes and intellectual ability implicate the thalamus.

التفاصيل البيبلوغرافية
العنوان: Genes contributing to subcortical volumes and intellectual ability implicate the thalamus.
المؤلفون: Bohlken MM; Department of Psychiatry, UMC Utrecht, The Netherlands., Brouwer RM, Mandl RC, van Haren NE, Brans RG, van Baal GC, de Geus EJ, Boomsma DI, Kahn RS, Hulshoff Pol HE
المصدر: Human brain mapping [Hum Brain Mapp] 2014 Jun; Vol. 35 (6), pp. 2632-42. Date of Electronic Publication: 2013 Sep 13.
نوع المنشور: Journal Article; Twin Study
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
مواضيع طبية MeSH: Intelligence* , Models, Genetic*, Thalamus/*anatomy & histology, Adult ; Brain/anatomy & histology ; Female ; Humans ; Image Processing, Computer-Assisted ; Intelligence Tests ; Magnetic Resonance Imaging ; Male ; Organ Size ; Sex Characteristics ; Siblings
مستخلص: It has been shown that brain volume and general intellectual ability are to a significant extent influenced by the same genetic factors. Several cortical regions of the brain also show a genetic correlation with intellectual ability, demonstrating that intellectual functioning is probably represented in a heritable distributed network of cortical regions throughout the brain. This study is the first to investigate a genetic association between subcortical volumes and intellectual ability, taking into account the thalamus, caudate nucleus, putamen, globus pallidus, hippocampus, amygdala, and nucleus accumbens using an extended twin design. Genetic modeling was performed on a healthy adult twin sample consisting of 106 twin pairs and 30 of their siblings, IQ data was obtained from 132 subjects. Our results demonstrate that of all subcortical volumes measured, only thalamus volume is significantly correlated with intellectual functioning. Importantly, the association found between thalamus volume and intellectual ability is significantly influenced by a common genetic factor. This genetic factor is also implicated in cerebral brain volume. The thalamus, with its widespread cortical connections, may thus play a key role in human intelligence.
(Copyright © 2013 Wiley Periodicals, Inc.)
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فهرسة مساهمة: Keywords: IQ; MRI; heritability; subcortical; thalamus; twin; volumetric
تواريخ الأحداث: Date Created: 20130917 Date Completed: 20141209 Latest Revision: 20240722
رمز التحديث: 20240722
مُعرف محوري في PubMed: PMC6869799
DOI: 10.1002/hbm.22356
PMID: 24038793
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0193
DOI:10.1002/hbm.22356