دورية أكاديمية
Mechanisms of hypertension in renal radiation.
| العنوان: | Mechanisms of hypertension in renal radiation. |
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| المؤلفون: | Juncos L; Instituto Privado de Especialidades Médicas, Córdoba, Argentina., Cornejo JC, Cejas H, Broglia C |
| المصدر: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 1990 Feb; Vol. 15 (2 Suppl), pp. I132-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print Cited Medium: Print ISSN: 0194-911X (Print) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
| مواضيع طبية MeSH: | Hypertension/*physiopathology , Kidney/*radiation effects, Animals ; Biomechanical Phenomena ; Blood Pressure/drug effects ; Creatine/blood ; Drinking/radiation effects ; Glomerular Filtration Rate ; Hypertension/etiology ; Hypertension/pathology ; Kidney/pathology ; Kidney Glomerulus/pathology ; Natriuresis/radiation effects ; Nephrectomy ; Radiation Injuries, Experimental ; Rats ; Rats, Inbred Strains ; Renin/blood ; Saralasin/pharmacology ; Sclerosis |
| مستخلص: | This study was undertaken to investigate the role played by renal functional and structural changes in the development of radiation-induced hypertension. Four groups of rats were studied: 1) left kidney radiated, 2) sham procedure, 3) uninephrectomy followed 3 weeks later by radiation of the contralateral kidney, and 4) uninephrectomy followed by sham procedure 3 weeks later. All radiated rats became hypertensive at 12 weeks (p less than 0.05) and had higher protein excretion (p less than 0.05). In the presence of an intact contralateral kidney, radiation causes mild-to-moderate histological abnormalities, and therefore, creatinine clearance and water and sodium handling do not change. Plasma renin activity increased in this group (p less than 0.05). Radiated uninephrectomized rats showed decreased creatinine clearance (p less than 0.05), but renin activity remained unchanged. These rats developed severe histological abnormalities in glomeruli, interstitia, tubuli, and vessels resulting in increased sodium and water output. The average of individual tubular and interstitial scores correlated significantly with both water intake and output but not with sodium excretion. These studies suggest that in the presence of an intact kidney, renin is an important determinant in the development or maintenance of radiation hypertension, whereas in the absence of the contralateral kidney, severe histological changes and renal failure are prominent despite increased water intake and output. The more severe glomerular sclerosis and proteinuria in the latter model could be related to diminished renal mass. |
| المشرفين على المادة: | EC 3.4.23.15 (Renin) H2AFV2HE66 (Saralasin) MU72812GK0 (Creatine) |
| تواريخ الأحداث: | Date Created: 19900201 Date Completed: 19900313 Latest Revision: 20190722 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1161/01.hyp.15.2_suppl.i132 |
| PMID: | 2404856 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0194-911X |
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| DOI: | 10.1161/01.hyp.15.2_suppl.i132 |