دورية أكاديمية
أعرض في EDS

Curcumin protection activities against γ-rays-induced molecular and biochemical lesions.

التفاصيل البيبلوغرافية
العنوان: Curcumin protection activities against γ-rays-induced molecular and biochemical lesions.
المؤلفون: Tawfik SS; Molecular Biology Department, National Research Centre, P, O, Box: 33211, Dokki, Cairo, Egypt. yassershahein_nrc@yahoo.com., Abouelella AM, Shahein YE
المصدر: BMC research notes [BMC Res Notes] 2013 Sep 21; Vol. 6, pp. 375. Date of Electronic Publication: 2013 Sep 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Biomed Central, 2008.
مواضيع طبية MeSH: Gamma Rays*, Curcumin/*pharmacology , Liver/*drug effects , Liver/*pathology , Radiation-Protective Agents/*pharmacology, Animals ; Blotting, Western ; Caspase 3/metabolism ; Catalase/metabolism ; Chromosome Aberrations/drug effects ; Chromosome Aberrations/radiation effects ; DNA Fragmentation/drug effects ; DNA Fragmentation/radiation effects ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Hydrogen Peroxide/metabolism ; Liver/enzymology ; Liver/radiation effects ; Male ; Mice ; Superoxide Dismutase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism ; Xanthine Oxidase/metabolism
مستخلص: Background: Curcumin is a yellow-pigment phenolic compound used as a food spice and has a broad spectrum of antioxidant, anti-carcinogenic, anti-mutagenic and anti-inflammatory properties.
Methods: Radio-protective efficacy of curcumin; diferuloylmethane (C21H20O6) was evaluated using molecular and biochemical assays in male mice after exposure to 3 Gy γ-rays. Curcumin was given at a dose of 400 μmol/ kg body weight via gastric tubes for 5 following days either pre-, post- or both pre- and post-exposure.
Results: The incidence of aberrant cells and aberration types (mostly chromatids, breaks and fragments) was reduced with curcumin dosage as compared to irradiated group. Thiobarbituric acid reactive substances (TBARS), hydroperoxide (HP), xanthine oxidase (XO) and apoptotic markers (DNA- fragmentation and caspase-3 activation) were increased significantly, whereas levels of glutathione (GSH) and the enzymatic antioxidants [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] were significantly depleted in γ-irradiated mice. Curcumin treatments of mice groups including the 5 days pre-irradiation treated group (protected), the 5 days post-irradiation treated group (treated), and the curcumin treated group 5 days pre- and post-irradiation (protracted), have attenuated the liver toxic effects of γ-rays as manifested by reducing the levels of TBARS, HP, XO and DNA fragmentation. Curcumin has also rescued the depletion of GSH and the enzymatic-antioxidant status.
Conclusions: Curcumin has significant radio-protective and radio-recovery activities in γ-irradiated mice. It has antioxidant potential against γ-rays-induced cytogenetic, molecular and biochemical lesions in mice.
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المشرفين على المادة: 0 (Radiation-Protective Agents)
0 (Thiobarbituric Acid Reactive Substances)
BBX060AN9V (Hydrogen Peroxide)
EC 1.11.1.6 (Catalase)
EC 1.11.1.9 (Glutathione Peroxidase)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.17.3.2 (Xanthine Oxidase)
EC 3.4.22.- (Caspase 3)
GAN16C9B8O (Glutathione)
IT942ZTH98 (Curcumin)
تواريخ الأحداث: Date Created: 20130924 Date Completed: 20140911 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3851857
DOI: 10.1186/1756-0500-6-375
PMID: 24053347
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-0500
DOI:10.1186/1756-0500-6-375