دورية أكاديمية
Stability and change in symptoms, cognition, and community outcome in schizophrenia.
| العنوان: | Stability and change in symptoms, cognition, and community outcome in schizophrenia. |
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| المؤلفون: | Miles AA; Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. Electronic address: amiles@yorku.ca., Heinrichs RW; Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. Electronic address: walterh@yorku.ca., Ammari N; Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. Electronic address: ammarina@yorku.ca., Hartman L; Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. Electronic address: lhartman@yorku.ca., McDermid Vaz S; Cleghorn Program (Early Intervention in Psychosis & Psychotic Disorders Clinic), St. Joseph's Healthcare, 25 Charlton Ave East, Suite 703, Hamilton, Ontario L8N 1Y2, Canada; Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main Street West, Hamilton Ontario L8S 4L8, Canada. Electronic address: smcdermi@stjosham.on.ca., Muharib E; Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. Electronic address: evarsm@yorku.ca. |
| المصدر: | Schizophrenia research [Schizophr Res] 2014 Feb; Vol. 152 (2-3), pp. 435-9. Date of Electronic Publication: 2013 Sep 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988- |
| مواضيع طبية MeSH: | Independent Living* , Schizophrenic Psychology*, Cognition Disorders/*epidemiology , Cognition Disorders/*etiology , Schizophrenia/*complications , Schizophrenia/*epidemiology, Disability Evaluation ; Female ; Humans ; Male ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Regression Analysis ; Residence Characteristics |
| مستخلص: | It has been well established that neurocognitive deficits are a core feature in schizophrenia and predict difficulties in functional independence. However, few studies have assessed the longitudinal stability of cognition and key aspects of functional outcome concurrently. Even less attention has been directed at the contingency of cognitive change on real world outcome changes. Accordingly, this study will assess the extent to which significant changes in cognition and community status are independent or related. As a point of comparison, the stability of clinical symptom status and the relationship between symptom and outcome change are evaluated. Symptoms, cognitive abilities, and community outcome was assessed in 128 patients with schizophrenia at baseline and again one year later. Intraclass correlation coefficients were used to index stability and reliable change index analyses quantified the prevalence of significant improvement or deterioration in each of the three illness features. Results from these analyses revealed that symptom status, cognitive functioning, and community outcome are similarly stable in treated schizophrenia outpatients. A small proportion of the sample demonstrated significant improvement or deterioration in these domains, with only weak evidence that such change was predicted by changes in symptoms or cognition. Further, there was no strong evidence of a preferential relationship for cognition relative to symptoms in relation to functional outcome. These results shed light on the strength and nature of the cognition-real world outcome relationship in schizophrenia and have implications for pharmacological and behavioral interventions aimed at improving real world outcome. (© 2013 Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | Canada Canadian Institutes of Health Research |
| فهرسة مساهمة: | Keywords: Change; Cognition; Functional outcome; Schizophrenia; Stability; Symptoms |
| تواريخ الأحداث: | Date Created: 20131002 Date Completed: 20140923 Latest Revision: 20160526 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.schres.2013.09.006 |
| PMID: | 24080456 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2509 |
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| DOI: | 10.1016/j.schres.2013.09.006 |