دورية أكاديمية
أعرض في EDS

The link of unintentional weight loss to cardiac event-free survival in patients with heart failure.

التفاصيل البيبلوغرافية
العنوان: The link of unintentional weight loss to cardiac event-free survival in patients with heart failure.
المؤلفون: Song EK; Eun Kyeung Song, PhD, RN Assistant Professor, Department of Nursing, College of Medicine, University of Ulsan, Korea. Yongjik Lee, MD Assistant Professor, Department of Thoracic and Cardiovascular Surgery, College of Medicine, University of Ulsan, Ulsan University Hospital, Korea. Debra K. Moser, DNSc, RN Professor, College of Nursing, University of Kentucky, Lexington. Rebecca L. Dekker, PhD, APRN Assistant Professor, College of Nursing, University of Kentucky, Lexington. Seok-Min Kang, MD, PhD Professor, Cardiology Division, Severance Hospital, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Seoul, Korea. Terry A. Lennie, PhD, RN Professor, College of Nursing, University of Kentucky, Lexington., Lee Y, Moser DK, Dekker RL, Kang SM, Lennie TA
المصدر: The Journal of cardiovascular nursing [J Cardiovasc Nurs] 2014 Sep-Oct; Vol. 29 (5), pp. 439-47.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8703516 Publication Model: Print Cited Medium: Internet ISSN: 1550-5049 (Electronic) Linking ISSN: 08894655 NLM ISO Abbreviation: J Cardiovasc Nurs Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: [Frederick, MD : Aspen Publishers, c1986-
مواضيع طبية MeSH: Weight Loss*/physiology, Heart Failure/*complications, Adult ; Aged ; Aged, 80 and over ; C-Reactive Protein/analysis ; Disease-Free Survival ; Female ; Heart Failure/mortality ; Humans ; Logistic Models ; Male ; Middle Aged ; Nutritional Status ; Prospective Studies
مستخلص: Background: Patients with heart failure (HF) commonly have unintentional weight loss, depressive symptoms, and elevated levels of high-sensitivity C-reactive protein (hsCRP). Each of these variables has been independently associated with shorter cardiac event-free survival. However, little data exist on the relationships of unintentional weight loss, hsCRP level, and depressive symptoms to cardiac event-free survival.
Objective: The aims of this study were to determine (1) whether depressive symptoms and elevated hsCRP level predicted unintentional weight loss and (2) whether unintentional weight loss predicted shorter cardiac event-free survival.
Methods: This was a prospective study of 243 consecutive HF patients (61% men, 61 ± 14 years old) enrolled during an index hospitalization for HF exacerbation. Patients provided blood samples to measure hsCRP level and completed the Beck Depression Inventory to assess depressive symptoms at discharge. Body weight was measured at discharge and 6 months later. Unintentional weight loss was defined as weight loss of greater than 6% of body weight since discharge. Cardiac event-free survival was followed for 1 year after the second measurement of body weight through monthly telephone interviews. Hierarchical logistic regression was used to determine whether depressive symptoms and elevated hsCRP level predicted unintentional weight loss. Cox hazard regression was used to determine whether unintentional weight loss predicted cardiac event-free survival.
Results: Thirty-five patients (14.4%) experienced unintentional weight loss at 6 months after discharge. Hierarchical Cox hazard regression revealed that patients with unintentional weight loss had a 3.2 times higher risk for cardiac events, adjusting for other clinical factors (P < .001). In hierarchical logistic regression, elevated hsCRP level (odds ratio, 1.49; 95% confidence interval, 1.15-1.92) and depressive symptoms (odds ratio, 1.07, 95% confidence interval, 1.02-1.12) independently predicted unintentional weight loss.
Conclusions: Unintentional weight loss was an independent predictor of poor outcomes. Heart failure patients with depressive symptoms and elevated hsCRP levels are at a higher risk for unintentional weight loss.
References: Gen Hosp Psychiatry. 2003 Jul-Aug;25(4):246-52. (PMID: 12850656)
Circulation. 2005 Sep 6;112(10):1428-34. (PMID: 16129801)
Pharmacol Ther. 2009 Mar;121(3):227-52. (PMID: 19061914)
Immunol Allergy Clin North Am. 2009 May;29(2):381-93. (PMID: 19389588)
Circulation. 1993 Jul;88(1):107-15. (PMID: 8319323)
Curr Opin Clin Nutr Metab Care. 2006 Jan;9(1):18-23. (PMID: 16340656)
J Clin Invest. 2005 Feb;115(2):451-8. (PMID: 15650772)
Am Heart J. 2005 Jul;150(1):132-6. (PMID: 16084159)
N Engl J Med. 2002 Nov 14;347(20):1557-65. (PMID: 12432042)
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11696-701. (PMID: 12975524)
Heart Lung. 2011 Nov-Dec;40(6):492-501. (PMID: 21453972)
Gen Hosp Psychiatry. 2008 Mar-Apr;30(2):127-37. (PMID: 18291294)
Circulation. 2003 Jan 28;107(3):363-9. (PMID: 12551853)
Int J Cardiol. 2009 Jul 10;135(3):396-7. (PMID: 18501446)
Appetite. 2000 Aug;35(1):65-71. (PMID: 10896762)
Clin Nurse Spec. 2007 Jul-Aug;21(4):203-11; quiz 212-3. (PMID: 17622809)
Int J Cardiol. 2008 Oct 13;129(3):363-7. (PMID: 18022259)
Eur Heart J. 2008 Nov;29(21):2641-50. (PMID: 18819960)
J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716)
N Engl J Med. 1999 Aug 5;341(6):427-34. (PMID: 10432328)
Curr Opin Clin Nutr Metab Care. 2005 May;8(3):249-54. (PMID: 15809526)
Clin Nutr. 2008 Dec;27(6):793-9. (PMID: 18718696)
J Am Coll Cardiol. 2006 Oct 17;48(8):1527-37. (PMID: 17045884)
Curr Opin Support Palliat Care. 2009 Dec;3(4):276-81. (PMID: 19797959)
J Cardiovasc Nurs. 2010 Nov-Dec;25(6):450-60. (PMID: 20938248)
Med Sci Monit. 2010 Mar;16(3):CR156-161. (PMID: 20190687)
Lancet. 1997 Apr 12;349(9058):1050-3. (PMID: 9107242)
Heart Fail Clin. 2011 Jan;7(1):23-38. (PMID: 21109205)
Curr Opin Support Palliat Care. 2007 Dec;1(4):299-305. (PMID: 18685379)
Lancet. 2003 Mar 29;361(9363):1077-83. (PMID: 12672310)
Behav Res Methods. 2007 May;39(2):175-91. (PMID: 17695343)
Am J Cardiol. 2004 Nov 15;94(10):1326-8. (PMID: 15541260)
Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):384-91. (PMID: 19474718)
Clin Cardiol. 1996 Jun;19(6):455-60. (PMID: 8790948)
J Nutr Health Aging. 2008 May;12(5):313-8. (PMID: 18443713)
Circulation. 2003 Sep 23;108(12):e81-5. (PMID: 14504253)
Int J Biochem Cell Biol. 2005 Oct;37(10):1938-47. (PMID: 15927519)
Int J Cardiol. 2002 Sep;85(1):51-66. (PMID: 12163209)
Int J Geriatr Psychiatry. 2007 Mar;22(3):218-23. (PMID: 17044132)
Int J Cardiol. 2000 Nov-Dec;76(2-3):117-22. (PMID: 11104865)
معلومات مُعتمدة: K23 NR013480 United States NR NINR NIH HHS
المشرفين على المادة: 9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20131004 Date Completed: 20151015 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4130800
DOI: 10.1097/JCN.0b013e3182a46ba8
PMID: 24088622
قاعدة البيانات: MEDLINE
الوصف
تدمد:1550-5049
DOI:10.1097/JCN.0b013e3182a46ba8