دورية أكاديمية
أعرض في EDS

Presence of Arp specifically contributes to joint tissue edema associated with early-onset Lyme arthritis.

التفاصيل البيبلوغرافية
العنوان: Presence of Arp specifically contributes to joint tissue edema associated with early-onset Lyme arthritis.
المؤلفون: Hove PR; Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA., Haldorson GJ, Magunda F, Bankhead T
المصدر: Infection and immunity [Infect Immun] 2014 Jan; Vol. 82 (1), pp. 43-51. Date of Electronic Publication: 2013 Oct 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington, DC : American Society For Microbiology
Original Publication: [Bethesda, Md.] American Society for Microbiology.
مواضيع طبية MeSH: Bacterial Proteins/*genetics , Borrelia burgdorferi/*genetics , Joint Diseases/*etiology , Lyme Disease/*genetics, Age of Onset ; Analysis of Variance ; Animals ; Bacterial Load ; Bacterial Proteins/metabolism ; Borrelia burgdorferi/pathogenicity ; Disease Models, Animal ; Edema/pathology ; Gene Deletion ; Joint Diseases/microbiology ; Joint Diseases/pathology ; Lyme Disease/microbiology ; Lyme Disease/pathology ; Lyme Disease/physiopathology ; Mice ; Mice, Inbred C3H ; Tarsal Joints/microbiology ; Tibia
مستخلص: Antiserum to the Borrelia burgdorferi arthritis-related protein, Arp, has been shown to prevent or reduce arthritis in immunodeficient mice. To directly investigate the requirement for this lipoprotein in the generation of Lyme arthritis, we utilized targeted deletion to generate a B. burgdorferi clone that lacked only the arp gene locus. Infection of Lyme disease-susceptible C3H/HeN mice with the arp deletion mutant demonstrated significantly reduced tibiotarsal joint swelling during the first 6 weeks of infection compared to a wild-type control. The severity of joint swelling was restored to wild-type levels in mice infected with an arp mutant clone complemented in cis. Interestingly, the reduced swelling of joint tissues exhibited by mice infected with the arp deletion mutant did not directly correspond to reduced underlying arthritis. Histopathology data at 2 weeks postinfection showed some reduction in arthritis severity caused by the arp mutant clone; however, by 8 weeks, no significant difference was observed between joint tissues infected by the wild-type or arp mutant clones. The spirochete load in the joint tissues of mice infected with the arp mutant was found to be greater than that exhibited by the wild-type control. Our findings demonstrate that this lipoprotein contributes to the generation of early-onset joint swelling and suggests that arp expression has a negative secondary effect on total spirochete numbers in joint tissues.
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المشرفين على المادة: 0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20131009 Date Completed: 20140219 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3911854
DOI: 10.1128/IAI.01061-13
PMID: 24101694
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-5522
DOI:10.1128/IAI.01061-13