دورية أكاديمية
CD133 expression in normal skin and in epithelial cutaneous tumors.
| العنوان: | CD133 expression in normal skin and in epithelial cutaneous tumors. |
|---|---|
| المؤلفون: | Nam-Cha SH; Department of Pathology, University General Hospital, 03003 Albacete, Spain., Serrano-Vargas R, Escario E, Azaña JM, Calero-Oliver R, Martín AG, Poblet E |
| المصدر: | BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 385604. Date of Electronic Publication: 2013 Sep 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Hindawi Pub. Co. |
| مواضيع طبية MeSH: | Neoplastic Stem Cells*, Antigens, CD/*biosynthesis , Carcinoma, Squamous Cell/*genetics , Glycoproteins/*biosynthesis , Neoplasms, Glandular and Epithelial/*genetics , Skin Neoplasms/*genetics, AC133 Antigen ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD/genetics ; Biomarkers, Tumor/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Differentiation/genetics ; Cell Line, Tumor ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic/genetics ; Glycoproteins/genetics ; Humans ; Male ; Middle Aged ; Neoplasms, Glandular and Epithelial/pathology ; Peptides/genetics ; Primary Cell Culture ; Skin Neoplasms/pathology |
| مستخلص: | Background: Expression of human CD133 (human prominin-1) in cancer cells has been postulated to be a marker of stemness and is considered as a putative marker of cancer stem cells (CSCs). We designed a study to describe the expression pattern of CD133 in normal skin and in epithelial cutaneous neoplasms. Methods: The CD133 immunohistochemical expression of forty-three eccrine and apocrine tumors was compared to that observed in other epithelial tumors of the skin. In addition, flow cytometry was used to detect the CD133 expression of four epithelial skin neoplasms, including one porocarcinoma. Results: CD133 immunoreactivity at the apical or at the apicolateral surface of cells forming glandular structures was observed. Cells from solid areas of benign or malignant tumors were not stained. The porocarcinoma derived culture cells showed a 22% of CD133 positive cells using flow cytometry, while squamous cell carcinoma cultures contained less than 0.1%. Conclusions: These observations indicate that CD133 is a specific marker of glandular differentiation that could be included in the diagnostic panel of cutaneous tumors with possible eccrine or apocrine differentiation. However, the use of CD133 expression as a marker of CSCs should be interpreted with caution in experiments of skin. |
| References: | Br J Dermatol. 2010 Jul;163(1):107-14. (PMID: 20346020) J Am Soc Nephrol. 2006 Sep;17(9):2443-56. (PMID: 16885410) Blood. 1997 Dec 15;90(12):5013-21. (PMID: 9389721) J Histochem Cytochem. 2008 Nov;56(11):977-93. (PMID: 18645205) Br J Dermatol. 2011 Apr;164(4):696-711. (PMID: 21128907) Blood. 1997 Dec 15;90(12):5002-12. (PMID: 9389720) Cells Tissues Organs. 2008;188(1-2):127-38. (PMID: 18160824) BMC Cancer. 2008 Feb 08;8:48. (PMID: 18261235) Int J Cancer. 2008 Feb 15;122(4):761-8. (PMID: 17955491) Pathol Int. 2012 Dec;62(12):792-801. (PMID: 23252868) BMC Cancer. 2009 Jul 07;9:221. (PMID: 19583859) Cancer Res. 2007 Jun 15;67(12):5727-36. (PMID: 17575139) Br J Dermatol. 2007 Feb;156(2):378-80. (PMID: 17223883) Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12425-30. (PMID: 9356465) J Biol Chem. 2000 Feb 25;275(8):5512-20. (PMID: 10681530) Cell Tissue Res. 2005 Jan;319(1):15-26. (PMID: 15558321) Mod Pathol. 2007 Jan;20(1):102-7. (PMID: 17143262) Clin Cancer Res. 2008 Jan 1;14(1):123-9. (PMID: 18172261) Br J Dermatol. 2009 Dec;161(6):1317-22. (PMID: 19659472) Hum Mol Genet. 2000 Jan 1;9(1):27-34. (PMID: 10587575) Cancer Res. 2010 Jan 15;70(2):719-29. (PMID: 20068153) Biochem Biophys Res Commun. 2006 Dec 29;351(4):820-4. (PMID: 17097610) J Cell Sci. 2004 Jul 15;117(Pt 16):3539-45. (PMID: 15226377) Front Biosci (Landmark Ed). 2013 Jan 01;18:447-53. (PMID: 23276935) Br J Dermatol. 2008 Sep;159(4):952-5. (PMID: 18647309) J Pathol. 2008 Jan;214(1):3-9. (PMID: 18067118) |
| المشرفين على المادة: | 0 (AC133 Antigen) 0 (Antigens, CD) 0 (Biomarkers, Tumor) 0 (Glycoproteins) 0 (PROM1 protein, human) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20131009 Date Completed: 20140603 Latest Revision: 20211021 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC3786506 |
| DOI: | 10.1155/2013/385604 |
| PMID: | 24102054 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2314-6141 |
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| DOI: | 10.1155/2013/385604 |