دورية أكاديمية
Heparin induces Ca2+ release from the terminal cisterns of skeletal muscle sarcoplasmic reticulum.
| العنوان: | Heparin induces Ca2+ release from the terminal cisterns of skeletal muscle sarcoplasmic reticulum. |
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| المؤلفون: | Ritov VB, Men'shikova EV, Kozlov YP |
| المصدر: | FEBS letters [FEBS Lett] 1985 Aug 19; Vol. 188 (1), pp. 77-80. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print Cited Medium: Print ISSN: 0014-5793 (Print) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2016- : West Sussex : John Wiley & Sons Ltd. Original Publication: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies. |
| مواضيع طبية MeSH: | Calcium/*metabolism , Heparin/*pharmacology , Muscles/*metabolism , Sarcoplasmic Reticulum/*metabolism, Adenosine Triphosphate/pharmacology ; Animals ; Biological Transport/drug effects ; Calcium/pharmacology ; Kinetics ; Lasalocid/pharmacology ; Rabbits ; Ruthenium Red/pharmacology ; Sarcoplasmic Reticulum/drug effects ; Spectrometry, Fluorescence |
| مستخلص: | Using a Ca2+-selective electrode and the chlorotetracycline fluorescence technique, the effects of heparin on Ca2+ transport in the sarcoplasmic reticulum (SR) of skeletal muscles in the absence of oxalate were investigated. It was shown that heparin (0.5-10 micrograms/ml) causes a rapid release of 40-50 nmol Ca2+/mg protein from the terminal cistern SR vesicles bound to 130-150 nmol/mg protein of Ca2+ in the presence of ATP. However, heparin has practically no effect on the longitudinal cistern fraction of SR. The effects of heparin can be prevented by ruthenium red. No influence of heparin is observed in the case of the Ca2+-induced release of Ca2+ from the terminal cisterns. When the Ca2+ release is induced by heparin, no Ca2+-induced release of Ca2+ takes place. |
| المشرفين على المادة: | 11103-72-3 (Ruthenium Red) 8L70Q75FXE (Adenosine Triphosphate) 9005-49-6 (Heparin) SY7Q814VUP (Calcium) W7V2ZZ2FWB (Lasalocid) |
| تواريخ الأحداث: | Date Created: 19850819 Date Completed: 19850925 Latest Revision: 20190620 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0014-5793(85)80878-4 |
| PMID: | 2410295 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-5793 |
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| DOI: | 10.1016/0014-5793(85)80878-4 |