التفاصيل البيبلوغرافية
| العنوان: |
Relationship among diffusion tensor imaging, EEG activity, and cognitive status in mild cognitive impairment and Alzheimer's disease patients. |
| المؤلفون: |
Scrascia F; Unitá di Neurologia, Universitá Campus Bio-Medico, Roma, Italy., Curcio G, Ursini F, Trotta L, Quintiliani L, Migliore S, Altamura C, Pitocco F, Altavilla R, Melgari JM, Quattrocchi CC, Vernieri F |
| المصدر: |
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2014; Vol. 38 (4), pp. 939-50. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| مواضيع طبية MeSH: |
Diffusion Tensor Imaging*/methods , Electroencephalography*/methods, Alzheimer Disease/*diagnosis , Alzheimer Disease/*physiopathology , Cognitive Dysfunction/*diagnosis , Cognitive Dysfunction/*physiopathology, Aged ; Aged, 80 and over ; Alzheimer Disease/psychology ; Cognition/physiology ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Cognition Disorders/psychology ; Cognitive Dysfunction/psychology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Single-Blind Method |
| مستخلص: |
Magnetic resonance (MR) diffusion tensor imaging (DTI) can detect microstructural alterations by means of fractional anisotropy (FA) in patients with dementia, also in relation to cognitive status. The present study aimed at investigating the possible relation among white matter damage in DTI, quantitative electroencephalography (EEG) spectral power, and cognitive status in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients. Forty-seven subjects (8 moderate AD, 18 mild AD, 12 MCI, and 9 healthy controls) underwent brain MR, neuropsychological evaluation, and resting EEG recording. A progressive increase of EEG delta and theta spectral power was observed from controls to patients, mainly in more anterior areas, with a parallel widespread decrease of beta power. Moreover, a progressive decrease of FA from controls to patients in frontal areas and in the corpus callosum (genu) was observed. Correlation analyses indicated convergence among EEG rhythms changes, DTI values, and cognitive status mainly over anterior areas. The decrease of FA values and EEG spectral power changes might represent markers of neurodegenerative dysfunction, possibly preceding macrostructural atrophy. |
| فهرسة مساهمة: |
Keywords: Alzheimer's disease; brain activity; dementia; diffusion tensor imaging; mild cognitive impairment |
| تواريخ الأحداث: |
Date Created: 20131015 Date Completed: 20140817 Latest Revision: 20220410 |
| رمز التحديث: |
20221213 |
| DOI: |
10.3233/JAD-130788 |
| PMID: |
24121958 |
| قاعدة البيانات: |
MEDLINE |
