دورية أكاديمية
أعرض في EDS

Dysregulation in lung immunity - the protective and pathologic Th17 response in infection.

التفاصيل البيبلوغرافية
العنوان: Dysregulation in lung immunity - the protective and pathologic Th17 response in infection.
المؤلفون: Way EE; Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Chen K, Kolls JK
المصدر: European journal of immunology [Eur J Immunol] 2013 Dec; Vol. 43 (12), pp. 3116-24. Date of Electronic Publication: 2013 Oct 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Cystic Fibrosis/*immunology , Granulomatous Disease, Chronic/*immunology , Infections/*immunology , Lung/*immunology , Th17 Cells/*immunology, Animals ; Cystic Fibrosis/pathology ; Granulomatous Disease, Chronic/pathology ; Humans ; Infections/pathology ; Lung/pathology ; Th17 Cells/metabolism
مستخلص: Th17 cytokines can play both protective and pathologic roles in the airways. An emerging theme in Th17 cytokine biology is that these responses can mediate tissue pathology when downstream effector cells are dysfunctional, such as neutrophils lacking functional NADPH oxidase in the case of chronic granulomatous disease, or epithelial cells lacking appropriate ion transport as in the case of cystic fibrosis. In this Mini-Review we highlight recent advances in the protective and pathologic roles of Th17 cytokines in the context of infection at the pulmonary barrier.
(© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.)
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معلومات مُعتمدة: R01 HL062052 United States HL NHLBI NIH HHS; T32 AR052282 United States AR NIAMS NIH HHS; R37 HL079142 United States HL NHLBI NIH HHS; P60 AA009803 United States AA NIAAA NIH HHS; R37-HL079142 United States HL NHLBI NIH HHS; T32-5T32AR052282-10 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Animal models; CD4 T cells; Cellular immunology; Cytokines; Lung inflammation
تواريخ الأحداث: Date Created: 20131017 Date Completed: 20140317 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3947216
DOI: 10.1002/eji.201343713
PMID: 24130019
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4141
DOI:10.1002/eji.201343713