دورية أكاديمية
Ongoing spillover of Hantaan and Gou hantaviruses from rodents is associated with hemorrhagic fever with renal syndrome (HFRS) in China.
العنوان: | Ongoing spillover of Hantaan and Gou hantaviruses from rodents is associated with hemorrhagic fever with renal syndrome (HFRS) in China. |
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المؤلفون: | Wang W; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China., Wang MR, Lin XD, Guo WP, Li MH, Mei SH, Li ZM, Cong ML, Jiang RL, Zhou RH, Holmes EC, Plyusnin A, Zhang YZ |
المصدر: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2013 Oct 17; Vol. 7 (10), pp. e2484. Date of Electronic Publication: 2013 Oct 17 (Print Publication: 2013). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Orthohantavirus/*classification , Orthohantavirus/*isolation & purification , Hemorrhagic Fever with Renal Syndrome/*epidemiology , Hemorrhagic Fever with Renal Syndrome/*veterinary , Rodent Diseases/*epidemiology , Zoonoses/*epidemiology , Zoonoses/*virology, Animals ; China/epidemiology ; Cluster Analysis ; Orthohantavirus/genetics ; Hemorrhagic Fever with Renal Syndrome/virology ; Humans ; Incidence ; Mice ; Molecular Epidemiology ; Molecular Sequence Data ; Phylogeny ; Prevalence ; RNA, Viral/genetics ; Rats ; Rodent Diseases/virology ; Seasons ; Sequence Analysis, DNA |
مستخلص: | Background: Longquan City, Zhejiang province, China, has been seriously affected by hemorrhagic fever with renal syndrome (HFRS) since the first cases were registered in 1974. To understand the epidemiology and emergence of HFRS in Longquan, which may be indicative of large parts of rural China, we studied long-term incidence patterns and performed a molecular epidemiological investigation of the causative hantaviruses in human and rodent populations. Method/principal Findings: During 1974-2011, 1866 cases of HFRS were recorded in Longquan, including 20 deaths. In 2011, the incidence of HFRS remained high, with 19.61 cases/100,000 population, despite the onset of vaccination in 1997. During 1974-1998, HFRS cases in Longquan occurred mainly in winter, while in the past decade the peak of HFRS has shifted to the spring. Notably, the concurrent prevalence of rodent-borne hantaviruses in the region was also high. Phylogenetic analyses of viral sequences recovered from rodents in Longquan revealed the presence of novel genetic variants of Gou virus (GOUV) in Rattus sp. rats and Hantaan virus (HTNV) in the stripe field mice, respectively. Strikingly, viral sequences sampled from infected humans were very closely related to those from rodents. Conclusions/significance: HFRS represents an important public health problem in Longquan even after years of preventive measures. Our data suggest that continual spillover of the novel genetic variant of GOUV and the new genetic lineage of HTNV are responsible for the high prevalence of HFRS in humans. In addition, this is the first report of GOUV associated with human HFRS cases, and our data suggest that GOUV is now the major cause of HFRS in this region. |
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سلسلة جزيئية: | GENBANK JQ912697; JQ912698; JQ912699; JQ912700; JQ912701; JQ912702; JQ912703; JQ912704; JQ912705; JQ912706; JQ912707; JQ912708; JQ912709; JQ912710; JQ912711; JQ912712; JQ912713; JQ912714; JQ912715; JQ912716; JQ912717; JQ912718; JQ912719; JQ912720; JQ912721; JQ912722; JQ912723; JQ912724; JQ912725; JQ912726; JQ912727; JQ912728; JQ912729; JQ912730; JQ912731; JQ912732; JQ912733; JQ912734; JQ912735; JQ912736; JQ912737; JQ912738; JQ912739; JQ912740; JQ912741; JQ912742; JQ912743; JQ912744; JQ912745; JQ912746; JQ912747; JQ912748; JQ912749; JQ912750; JQ912751; JQ912752; JQ912753; JQ912754; JQ912755; JQ912756; JQ912757; JQ912758; JQ912759; JQ912760; JQ912761; JQ912762; JQ912763; JQ912764; JQ912765; JQ912766; JQ912767; JQ912768; JQ912769; JQ912770; JQ912771; JQ912772; JQ912773; JQ912774; JQ912775; JQ912776; JQ912777; JQ912778; JQ912779; JQ912780; JQ912781; JQ912782; JQ912783; JQ912784; JQ912785; JQ912786; JQ912787; JQ912788; JQ912789; JQ912790; JQ912791; JQ912792; JQ912793; JQ912794; JQ912795; JQ912796; JQ912797; JQ912798; JQ912799; JQ912800; JQ912801; JQ912802; JQ912803; JQ912804; JQ912805; JQ912806; JQ912807; JQ912808; JQ912809; JQ912810; JQ912811; JQ912812; JQ912813; JQ912814; JQ912815; JQ912816; JQ912817; JQ912818; JQ912819; JQ912820; JQ912821; JQ912822; JQ912823; JQ912824; JQ912825; JQ912826; JQ912827; JQ912828; JQ912829; JQ912830; JQ912831; JQ912832; JQ912833; JQ912834; JQ912835; JQ912836; JQ912837; JQ912838; JQ912839; JQ912840; JQ912841; JQ912842; JQ912843; JQ912844; JQ912845; JQ912846; JQ912847; JQ912848; JQ912849; JQ912850; JQ912851; JQ912852; JQ912853; JQ912854; JQ912855; JQ912856; JQ912857; JQ912858; JQ912859; JQ912860; JQ912861; JQ912862; JQ912863; JQ912864; JQ912865; JQ912866; JQ912867; JQ912868; JQ912869; JQ912870; JQ912871; JQ912872; JQ912873; JQ912874; JQ912875; JQ912876; JQ912877; JQ912878; JQ912879; JQ912880; JQ912881; JQ912882; JQ912883; JQ912884; JQ912885; JQ912886; JQ912887; JQ912888; JQ912889; JQ912890; JQ912891; JQ912892; JQ912893; JQ912894; JQ912895; JQ912896; JQ912897; JQ912898; JQ912899; JQ912900; JQ912901; JQ912902; JQ912903; JQ912904; JQ912905; JQ912906; JQ912907; KC344236; KC344237; KC344238; KC344239; KC344240; KC344241; KC344242; KC344243; KC344244; KC344245; KC344246; KC344247; KC344248; KC344249; KC344250; KC344251; KC344252; KC344253; KC344254; KC344255; KC344256; KC344257; KC344258; KC344259; KC344260; KC344261; KC344262; KC344263; KC344264; KC344265; KC344266; KC344267; KC344268; KC344269 |
المشرفين على المادة: | 0 (RNA, Viral) |
تواريخ الأحداث: | Date Created: 20131023 Date Completed: 20140505 Latest Revision: 20221207 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC3798614 |
DOI: | 10.1371/journal.pntd.0002484 |
PMID: | 24147168 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1935-2735 |
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DOI: | 10.1371/journal.pntd.0002484 |