دورية أكاديمية
[Liver disorders in adults: ALT and AST].
| العنوان: | [Liver disorders in adults: ALT and AST]. |
|---|---|
| عنوان ترانسليتريتد: | Leveraandoeningen bij volwassenen: ALAT en ASAT. |
| المؤلفون: | Goorden SM, Buffart TE, Bakker A, Buijs MM |
| المصدر: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2013; Vol. 157 (43), pp. A6443. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Dutch; Flemish |
| بيانات الدورية: | Publisher: Vereniging NTvG Country of Publication: Netherlands NLM ID: 0400770 Publication Model: Print Cited Medium: Internet ISSN: 1876-8784 (Electronic) Linking ISSN: 00282162 NLM ISO Abbreviation: Ned Tijdschr Geneeskd Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017?-: Amsterdam : Vereniging NTvG Original Publication: Houten : Bohn Stafleu van Loghum |
| مواضيع طبية MeSH: | Alanine Transaminase/*blood , Aspartate Aminotransferases/*blood , Fatty Liver/*enzymology , Liver Diseases/*enzymology, Adult ; Aged ; Biomarkers/blood ; Diagnosis, Differential ; Fatty Liver/diagnosis ; Female ; Humans ; Liver Diseases/diagnosis ; Non-alcoholic Fatty Liver Disease ; Reference Values |
| مستخلص: | Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are commonly used biomarkers for liver damage. As well as in liver tissue, AST is also present in cardiac and skeletal muscle and in erythrocytes, making ALT the most specific marker for liver damage. Here, we describe two patients with sustained increases in ALT and AST levels. The first patient is a 79-year-old woman who developed elevated serum transaminases shortly after having a myocardial infarction. The second patient, an obese 40-year-old woman presented with increased ALT and AST levels in the absence of physical symptoms. Notably, her father died of liver cirrhosis without a history of alcohol abuse. Based upon these case reports we discuss the differential diagnostic work-up of elevated serum transaminase levels. Furthermore, we explain monitoring, test performance, reference values and analytical pitfalls of these biomarkers. |
| المشرفين على المادة: | 0 (Biomarkers) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) |
| تواريخ الأحداث: | Date Created: 20131025 Date Completed: 20140630 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| PMID: | 24152362 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-8784 |
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