دورية أكاديمية
Pubertal high fat diet: effects on mammary cancer development.
العنوان: | Pubertal high fat diet: effects on mammary cancer development. |
---|---|
المؤلفون: | Zhao Y, Tan YS, Aupperlee MD, Langohr IM, Kirk EL, Troester MA, Schwartz RC, Haslam SZ |
المصدر: | Breast cancer research : BCR [Breast Cancer Res] 2013; Vol. 15 (5), pp. R100. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Print Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: London, UK : BioMed Central Ltd Original Publication: London, UK : Current Science, c1999- |
مواضيع طبية MeSH: | Diet, High-Fat* , Sexual Maturation*, Breast Neoplasms/*etiology , Mammary Neoplasms, Experimental/*etiology, Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Proliferation ; Cytokines/metabolism ; Female ; Gene Expression Profiling ; Hormones/blood ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/mortality ; Mammary Neoplasms, Experimental/pathology ; Mice ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Signal Transduction ; Time Factors ; Tumor Microenvironment |
مستخلص: | Introduction: Epidemiological studies linking dietary fat intake and obesity to breast cancer risk have produced inconsistent results. This may be due to the difficulty of dissociating fat intake from obesity, and/or the lack of defined periods of exposure in these studies. The pubertal mammary gland is highly sensitive to cancer-causing agents. We assessed how high fat diet (HFD) affects inflammation, proliferative, and developmental events in the pubertal gland, since dysregulation of these can promote mammary tumorigenesis. To test the effect of HFD initiated during puberty on tumorigenesis, we utilized BALB/c mice, for which HFD neither induces obesity nor metabolic syndrome, allowing dissociation of HFD effects from other conditions associated with HFD. Methods: Pubertal BALB/c mice were fed a low fat diet (12% kcal fat) or a HFD (60% kcal fat), and subjected to carcinogen 7,12-dimethylbenz[a]anthracene (DMBA)-induced tumorigenesis. Results: HFD elevated mammary gland expression of inflammatory and growth factor genes at 3 and 4 weeks of diet. Receptor activator of nuclear factor kappa-B ligand (RANKL), robustly induced at 4 weeks, has direct mitogenic activity in mammary epithelial cells and, as a potent inducer of NF-κB activity, may induce inflammatory genes. Three weeks of HFD induced a transient influx of eosinophils into the mammary gland, consistent with elevated inflammatory factors. At 10 weeks, prior to the appearance of palpable tumors, there were increased numbers of abnormal mammary epithelial lesions, enhanced cellular proliferation, increased growth factors, chemokines associated with immune-suppressive regulatory T cells, increased vascularization, and elevated M2 macrophages. HFD dramatically reduced tumor latency. Early developing tumors were more proliferative and were associated with increased levels of tumor-related growth factors, including increased plasma levels of HGF in tumor-bearing animals. Early HFD tumors also had increased vascularization, and more intra-tumor and stromal M2 macrophages. Conclusions: Taken together in this non-obesogenic context, HFD promotion of inflammatory processes, as well as local and systemically increased growth factor expression, are likely responsible for the enhanced tumorigenesis. It is noteworthy that although DMBA mutagenesis is virtually random in its targeting of genes in tumorigenesis, the short latency tumors arising in animals on HFD showed a unique gene expression profile, highlighting the potent overarching influence of HFD. |
References: | PLoS One. 2011 Apr 29;6(4):e19495. (PMID: 21559338) Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9744-9. (PMID: 12897242) Dev Biol. 2009 Apr 1;328(1):127-39. (PMID: 19298785) Ann N Y Acad Sci. 1996 Apr 30;784:189-201. (PMID: 8651569) J Nutr Biochem. 2010 Jun;21(6):550-5. (PMID: 19361974) Cancer Prev Res (Phila). 2012 Feb;5(2):216-28. (PMID: 22166249) Nutr Cancer. 2011;63(3):410-20. (PMID: 21391126) PLoS One. 2011;6(9):e24671. (PMID: 21935436) Eur Rev Med Pharmacol Sci. 2012 Jul;16(7):958-65. (PMID: 22953646) Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1179-87. (PMID: 15671082) Cancer Res. 1993 Aug 15;53(16):3736-40. (PMID: 8339284) J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):181-94. (PMID: 18470483) Breast Cancer Res. 2012 Feb 07;14(1):R23. (PMID: 22314082) Endocrinology. 2009 Dec;150(12):5218-29. (PMID: 19819943) Cell. 2008 Aug 8;134(3):392-404. (PMID: 18692464) J Carcinog. 2011;10:40. (PMID: 22368515) Diabetes. 2007 Oct;56(10):2501-10. (PMID: 17664243) Oncogene. 2000 Feb 21;19(8):968-88. (PMID: 10713680) Cell. 2010 Apr 2;141(1):39-51. (PMID: 20371344) Apoptosis. 2002 Apr;7(2):167-71. (PMID: 11865201) Cell Signal. 2012 Apr;24(4):961-8. (PMID: 22234345) Cell. 2005 May 6;121(3):335-48. (PMID: 15882617) Eur J Endocrinol. 2006 Feb;154(2):349-54. (PMID: 16452551) Nutrition. 1996 Jan;12(1 Suppl):S24-6. (PMID: 8850215) Proc Nutr Soc. 2008 May;67(2):128-45. (PMID: 18412987) Horm Cancer. 2010 Apr;1(2):71-9. (PMID: 21113329) Breast Cancer Res. 2011 Aug 11;13(4):R78. (PMID: 21834963) J Biol Chem. 1998 Aug 7;273(32):20551-5. (PMID: 9685412) Cancer. 1999 Jun 1;85(11):2400-9. (PMID: 10357411) Cancer Res. 2001 Mar 15;61(6):2782-7. (PMID: 11289162) Breast Cancer Res. 2004;6(5):192-200. (PMID: 15318924) Breast Cancer Res Treat. 2008 May;109(1):123-39. (PMID: 17578664) Mol Cell Endocrinol. 2004 Oct 15;225(1-2):77-82. (PMID: 15451571) Cell. 2002 Jan 25;108(2):171-82. (PMID: 11832208) Int J Biochem Cell Biol. 2009 May;41(5):986-9. (PMID: 18760377) PLoS One. 2011;6(12):e29524. (PMID: 22216303) Science. 1999 Apr 2;284(5411):156-9. (PMID: 10102818) J Neuroendocrinol. 2012 Aug;24(8):1120-5. (PMID: 22487415) Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2989-94. (PMID: 20133621) Eur J Cancer. 1997 Apr;33(5):787-91. (PMID: 9282118) Trends Genet. 2012 Mar;28(3):128-36. (PMID: 22265392) J Natl Cancer Inst. 2007 Mar 21;99(6):451-62. (PMID: 17374835) Eur J Cancer. 2004 Mar;40(4):494-502. (PMID: 14962714) J Nutr. 1995 Feb;125(2):229-37. (PMID: 7861250) Breast Cancer Res. 2002;4(4):155-64. (PMID: 12100741) Blood. 1990 Jul 1;76(1):50-6. (PMID: 2114187) Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2302-6. (PMID: 9482880) Arthritis Res. 2000;2(3):189-202. (PMID: 11094428) Nutr Cancer. 2004;50(2):174-80. (PMID: 15623464) J Mammary Gland Biol Neoplasia. 2000 Jan;5(1):7-17. (PMID: 10791764) Br J Nutr. 2012 Jan;107(2):229-41. (PMID: 21733316) Stem Cells. 2013 Feb;31(2):248-58. (PMID: 23169551) Am J Clin Nutr. 2007 Nov;86(5):1286-92. (PMID: 17991637) Breast Cancer Res. 2012 May 21;14(3):105. (PMID: 22643182) Exp Cell Res. 1997 Aug 25;235(1):218-26. (PMID: 9281371) Breast Cancer Res. 2007;9(6):R91. (PMID: 18162139) Nat Rev Immunol. 2003 Jan;3(1):23-35. (PMID: 12511873) J Biol Chem. 2003 Nov 14;278(46):46171-8. (PMID: 12952963) Curr Opin Pharmacol. 2009 Aug;9(4):351-69. (PMID: 19665429) Int J Cancer. 2008 May 15;122(10):2286-93. (PMID: 18224687) J Clin Oncol. 2012 Mar 1;30(7):729-34. (PMID: 22291085) Science. 2006 Oct 13;314(5797):298-300. (PMID: 17038622) Clin Exp Metastasis. 2012 Apr;29(4):327-38. (PMID: 22274590) Semin Liver Dis. 2010 Aug;30(3):245-57. (PMID: 20665377) J Exp Med. 1997 Jun 16;185(12):2171-6. (PMID: 9182688) Oncogene. 2002 Oct 17;21(47):7214-25. (PMID: 12370811) Breast Cancer Res. 2010;12(6):213. (PMID: 21067528) Breast Cancer Res. 2007;9(4):211. (PMID: 17705881) Breast Cancer Res Treat. 2010 Aug;122(3):647-59. (PMID: 19851863) Environ Health Perspect. 2009 Dec;117(12):1814-22. (PMID: 20049199) Biol Reprod. 2008 Oct;79(4):711-7. (PMID: 18614704) Am J Pathol. 2002 Jun;160(6):2081-93. (PMID: 12057913) Breast Cancer Res Treat. 2012 May;133(1):257-65. (PMID: 22270936) Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602. (PMID: 9520411) Cancer Res. 2006 Jan 15;66(2):605-12. (PMID: 16423985) Oncogene. 1990 Oct;5(10):1573-9. (PMID: 2250913) Breast Cancer Res Treat. 2010 Oct;123(3):641-9. (PMID: 20711809) Am J Pathol. 2003 Nov;163(5):2113-26. (PMID: 14578209) Cell. 2008 Jul 25;134(2):215-30. (PMID: 18662538) Arthritis Res. 2002;4 Suppl 3:S81-90. (PMID: 12110126) J Immunol. 1995 Dec 1;155(11):5299-305. (PMID: 7594543) Biochim Biophys Acta. 2013 Feb;1830(2):2268-79. (PMID: 22967760) BMC Physiol. 2010 Oct 19;10:20. (PMID: 20958969) Carcinogenesis. 2005 May;26(5):867-74. (PMID: 15471900) Endocrinology. 2005 Aug;146(8):3577-88. (PMID: 15878961) Endocrinology. 2009 Mar;150(3):1485-94. (PMID: 18988671) Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S21-35. (PMID: 22128285) Cytokine. 2013 Feb;61(2):377-88. (PMID: 23290315) Dev Biol. 2010 Jan 1;337(1):124-33. (PMID: 19850030) Mol Cell Biol. 2007 Feb;27(4):1442-54. (PMID: 17145767) Int J Obes (Lond). 2010 Sep;34(9):1415-26. (PMID: 20231845) J Immunol. 2010 Jun 15;184(12):6833-42. (PMID: 20483762) Science. 2011 Apr 8;332(6026):243-7. (PMID: 21436399) Int J Cancer. 2012 Feb 15;130(4):765-74. (PMID: 21455984) Dev Cell. 2009 Mar;16(3):329-43. (PMID: 19289080) J Exp Med. 1988 May 1;167(5):1737-42. (PMID: 2835420) Am J Epidemiol. 2000 Sep 15;152(6):514-27. (PMID: 10997541) Clin Cancer Res. 2012 May 15;18(10):2726-32. (PMID: 22474319) Toxicol Pathol. 2008 Oct;36(6):850-7. (PMID: 18812581) Clin Cancer Res. 1999 Jul;5(7):1935-44. (PMID: 10430101) Cell Immunol. 1995 Apr 15;162(1):114-22. (PMID: 7704899) Genes Cells. 2002 Apr;7(4):401-12. (PMID: 11952836) Obesity (Silver Spring). 2010 Nov;18(11):2234-6. (PMID: 20300079) Breast Cancer Res. 2003;5(4):208-15. (PMID: 12817994) Breast Cancer Res Treat. 1992;22(1):59-67. (PMID: 1421425) Cancer Res. 1998 Feb 15;58(4):654-60. (PMID: 9485017) Nat Rev Cancer. 2010 Feb;10(2):116-29. (PMID: 20094046) Biochem Biophys Res Commun. 2007 Mar 2;354(1):45-9. (PMID: 17210129) Cancer Res. 2003 Mar 1;63(5):1054-8. (PMID: 12615722) Methods Mol Biol. 2012;846:1-12. (PMID: 22367796) Endocr Rev. 2009 Feb;30(1):51-74. (PMID: 19075184) Mol Med Rep. 2012 Sep;6(3):591-6. (PMID: 22711074) Cancer Genet Cytogenet. 2000 Jun;119(2):83-93. (PMID: 10867141) Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5455-60. (PMID: 17369357) Cell. 1990 Jun 15;61(6):1147-55. (PMID: 2161707) Oncogene. 2005 Jun 9;24(25):4094-105. (PMID: 15897912) Endocrinology. 1990 Jan;126(1):596-607. (PMID: 2294006) BMC Cancer. 2011 May 30;11:213. (PMID: 21624121) Cancer Sci. 2010 Oct;101(10):2137-44. (PMID: 20608934) PLoS One. 2009;4(4):e5125. (PMID: 19340288) Am J Clin Nutr. 2008 Nov;88(5):1304-12. (PMID: 18996867) Cell Signal. 2010 Dec;22(12):1864-73. (PMID: 20667470) Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E145-54. (PMID: 20959532) Mod Pathol. 1998 Feb;11(2):155-68. (PMID: 9504686) J Cell Biol. 1982 Oct;95(1):285-95. (PMID: 6183270) Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E849-55. (PMID: 19638507) Breast Cancer Res. 2004;6(1):R1-7. (PMID: 14680494) |
معلومات مُعتمدة: | P30 ES010126 United States ES NIEHS NIH HHS; U01 ES019472 United States ES NIEHS NIH HHS; U01ES019472 United States ES NIEHS NIH HHS; U01ES012800 United States ES NIEHS NIH HHS; U01ESO19434 United States PHS HHS |
المشرفين على المادة: | 0 (Cytokines) 0 (Hormones) 0 (Inflammation Mediators) 0 (Intercellular Signaling Peptides and Proteins) |
تواريخ الأحداث: | Date Created: 20131026 Date Completed: 20140911 Latest Revision: 20211021 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3978633 |
DOI: | 10.1186/bcr3561 |
PMID: | 24156623 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1465-542X |
---|---|
DOI: | 10.1186/bcr3561 |