دورية أكاديمية
Snake venom PLA2s inhibitors isolated from Brazilian plants: synthetic and natural molecules.
العنوان: | Snake venom PLA2s inhibitors isolated from Brazilian plants: synthetic and natural molecules. |
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المؤلفون: | Carvalho BM; Chemistry, Biotechnology and Bioprocess Department, Federal University of São João Del Rei, 36420-000 Ouro Branco, MG, Brazil., Santos JD, Xavier BM, Almeida JR, Resende LM, Martins W, Marcussi S, Marangoni S, Stábeli RG, Calderon LA, Soares AM, Da Silva SL, Marchi-Salvador DP |
المصدر: | BioMed research international [Biomed Res Int] 2013; Vol. 2013, pp. 153045. Date of Electronic Publication: 2013 Sep 22. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Hindawi Pub. Co. |
مواضيع طبية MeSH: | Biological Products/*isolation & purification , Phospholipase A2 Inhibitors/*isolation & purification , Plants/*chemistry , Snake Venoms/*chemistry, Animals ; Biological Products/chemistry ; Brazil ; Phospholipase A2 Inhibitors/chemistry |
مستخلص: | Ophidian envenomation is an important health problem in Brazil and other South American countries. In folk medicine, especially in developing countries, several vegetal species are employed for the treatment of snakebites in communities that lack prompt access to serum therapy. However, the identification and characterization of the effects of several new plants or their isolated compounds, which are able to inhibit the activities of snake venom, are extremely important and such studies are imperative. Snake venom contains several organic and inorganic compounds; phospholipases A2 (PLA2s) are one of the principal toxic components of venom. PLA2s display a wide variety of pharmacological activities, such as neurotoxicity, myotoxicity, cardiotoxicity, anticoagulant, hemorrhagic, and edema-inducing effects. PLA2 inhibition is of pharmacological and therapeutic interests as these enzymes are involved in several inflammatory diseases. This review describes the results of several studies of plant extracts and their isolated active principles, when used against crude snake venoms or their toxic fractions. Isolated inhibitors, such as steroids, terpenoids, and phenolic compounds, are able to inhibit PLA2s from different snake venoms. The design of specific inhibitors of PLA2s might help in the development of new pharmaceutical drugs, more specific antivenom, or even as alternative approaches for treating snakebites. |
References: | Cell Mol Life Sci. 2006 Dec;63(24):3030-41. (PMID: 17103111) Pharm Biol. 2012 Mar;50(3):366-75. (PMID: 22133075) Phytother Res. 2008 Jul;22(7):859-66. (PMID: 18567056) Eur J Med Chem. 2009 Jan;44(1):312-21. (PMID: 18423943) Protein J. 2008 Sep;27(6):384-91. (PMID: 18766430) Toxicon. 1989;27(9):1003-9. (PMID: 2799833) Biochimie. 2000 Sep-Oct;82(9-10):815-31. (PMID: 11086212) Comp Biochem Physiol B Biochem Mol Biol. 2000 Sep;127(1):21-30. (PMID: 11126749) J Pharmacol Exp Ther. 2000 Sep;294(3):793-9. (PMID: 10945826) Int J Pediatr Otorhinolaryngol. 2012 Apr;76(4):471-4. (PMID: 22297210) Toxicon. 2011 Jan;57(1):100-8. (PMID: 21044643) J Comput Aided Mol Des. 2007 Aug;21(8):473-83. (PMID: 17701137) Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):249-52. (PMID: 21301098) Bioorg Med Chem Lett. 2004 Jan 19;14(2):431-5. (PMID: 14698175) J Alzheimers Dis. 2011;25(3):505-15. (PMID: 21471645) Phytomedicine. 2005 Jan;12(1-2):123-30. (PMID: 15693719) Toxicon. 1987;25(9):929-37. (PMID: 3433304) Toxicon. 2012 Oct;60(5):773-81. (PMID: 22750534) Biochimie. 2008 Oct;90(10):1506-14. (PMID: 18549822) Science. 2001 Nov 30;294(5548):1871-5. (PMID: 11729303) Biochimie. 2010 Aug;92(8):1063-71. (PMID: 20562011) Toxicon. 2008 Feb;51(2):240-50. (PMID: 17983638) Biochimie. 2003 Oct;85(10):1017-25. (PMID: 14644557) Biochemistry. 2002 Sep 10;41(36):10914-9. (PMID: 12206661) PLoS One. 2011;6(12):e28521. (PMID: 22205953) Toxicon. 2008 Nov;52(6):655-66. (PMID: 18718481) Phytochemistry. 2005 May;66(9):1017-25. (PMID: 15896371) Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jan;137(1):19-27. (PMID: 14984700) J Ethnopharmacol. 2007 Jul 25;112(3):490-7. (PMID: 17540522) J Venom Res. 2011;2:11-6. (PMID: 21654896) Bioorg Med Chem Lett. 2001 Feb 12;11(3):283-6. (PMID: 11212092) Rev Biol Trop. 2009 Dec;57(4):929-37. (PMID: 20073325) Planta Med. 2000 Jun;66(5):424-8. (PMID: 10909261) Toxicon. 2005 Sep 1;46(3):318-27. (PMID: 15992846) Cell Biol Int. 2007 Mar;31(3):263-8. (PMID: 17178238) Prog Nucleic Acid Res Mol Biol. 1998;59:307-64. (PMID: 9427847) J Ethnopharmacol. 2005 Dec 1;102(3):364-70. (PMID: 16084045) Plant Cell Rep. 2004 Mar;22(8):549-52. (PMID: 14727051) Toxicon. 1998 Dec;36(12):1749-800. (PMID: 9839663) Toxicon. 1987;25(5):501-15. (PMID: 3617087) Curr Opin Pediatr. 2005 Apr;17(2):234-8. (PMID: 15800419) J Struct Biol. 2010 Jul;171(1):31-43. (PMID: 20371382) Biochim Biophys Acta. 2003 Aug 21;1650(1-2):1-3. (PMID: 12922163) Biochem Biophys Res Commun. 2004 Jul 9;319(4):1314-21. (PMID: 15194511) Biochim Biophys Acta. 2009 Nov;1794(11):1583-90. (PMID: 19616648) Brain Res Bull. 1999 Jun;49(3):139-53. (PMID: 10435777) Molecules. 2010 Aug 30;15(9):5956-70. (PMID: 20877202) Curr Med Chem. 2005;12(22):2625-41. (PMID: 16248818) Proteins. 2008 Aug 15;72(3):883-91. (PMID: 18275084) Curr Pharm Des. 2007;13(28):2935-50. (PMID: 17979738) Arch Toxicol. 2011 Oct;85(10):1219-33. (PMID: 21331602) Chem Biol Interact. 2004 Dec 7;150(3):243-51. (PMID: 15560891) Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):293-9. (PMID: 19320636) Bioinformation. 2012;8(1):48-57. (PMID: 22359435) J Ethnopharmacol. 2005 Apr 8;98(1-2):213-6. (PMID: 15763387) Biochim Biophys Acta. 2008 Apr;1784(4):591-9. (PMID: 18261474) Toxicon. 2008 Jun 15;51(8):1467-78. (PMID: 18471841) Toxicon. 2001 Dec;39(12):1863-9. (PMID: 11600149) Curr Top Med Chem. 2011;11(20):2509-19. (PMID: 21682685) Curr Top Med Chem. 2007;7(8):743-56. (PMID: 17456038) Biologicals. 2002 Jun;30(2):143-51. (PMID: 12127316) Evid Based Complement Alternat Med. 2010 Sep;7(3):283-94. (PMID: 18955349) Toxicon. 1992 Oct;30(10):1211-8. (PMID: 1440627) Molecules. 2010 Nov 12;15(11):8193-204. (PMID: 21076386) Curr Pharm Des. 2010;16(28):3224-30. (PMID: 20687875) Phytochemistry. 2000 Nov;55(6):627-42. (PMID: 11130675) J Ethnopharmacol. 2005 Aug 22;100(1-2):145-52. (PMID: 16054531) Pediatr Crit Care Med. 2011 Jan;12(1):e20-4. (PMID: 20351613) Circulation. 2010 Nov 23;122(21):2183-200. (PMID: 21098459) Toxicon. 1996 Aug;34(8):827-41. (PMID: 8875770) |
المشرفين على المادة: | 0 (Biological Products) 0 (Phospholipase A2 Inhibitors) 0 (Snake Venoms) |
تواريخ الأحداث: | Date Created: 20131031 Date Completed: 20140612 Latest Revision: 20220318 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3793501 |
DOI: | 10.1155/2013/153045 |
PMID: | 24171158 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2314-6141 |
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DOI: | 10.1155/2013/153045 |