دورية أكاديمية
أعرض في EDS

Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity.

التفاصيل البيبلوغرافية
العنوان: Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity.
المؤلفون: Lage PS; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31.270-901, Brazil., de Andrade PH, Lopes Ade S, Chávez Fumagalli MA, Valadares DG, Duarte MC, Pagliara Lage D, Costa LE, Martins VT, Ribeiro TG, Filho JD, Tavares CA, de Pádua RM, Leite JP, Coelho EA
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2013; Vol. 2013, pp. 304354. Date of Electronic Publication: 2013 Sep 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis. A bioactivity-guided fractionation was performed, and two flavonoids were identified, quercetin 3-O-methyl ether and strychnobiflavone, which presented an effective antileishmanial activity against L. amazonensis, and studies were extended to establish their minimum inhibitory concentrations (IC50), their leishmanicidal effects on the intra-macrophage Leishmania stage, as well as their cytotoxic effects on murine macrophages (CC50), and in O+ human red blood cells. The data presented in this study showed the potential of an ethyl acetate extract of S. pseudoquina, as well as two flavonoids purified from it, which can be used as a therapeutic alternative on its own, or in association with other drugs, to treat disease evoked by L. amazonensis.
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تواريخ الأحداث: Date Created: 20131107 Date Completed: 20131106 Latest Revision: 20220317
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3806161
DOI: 10.1155/2013/304354
PMID: 24194781
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2013/304354