دورية أكاديمية
Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity.
العنوان: | Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity. |
---|---|
المؤلفون: | Lage PS; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31.270-901, Brazil., de Andrade PH, Lopes Ade S, Chávez Fumagalli MA, Valadares DG, Duarte MC, Pagliara Lage D, Costa LE, Martins VT, Ribeiro TG, Filho JD, Tavares CA, de Pádua RM, Leite JP, Coelho EA |
المصدر: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2013; Vol. 2013, pp. 304354. Date of Electronic Publication: 2013 Sep 30. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York, NY : Hindawi Pub. Original Publication: Oxford, UK : Oxford University Press, c2004- |
مستخلص: | The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis. A bioactivity-guided fractionation was performed, and two flavonoids were identified, quercetin 3-O-methyl ether and strychnobiflavone, which presented an effective antileishmanial activity against L. amazonensis, and studies were extended to establish their minimum inhibitory concentrations (IC50), their leishmanicidal effects on the intra-macrophage Leishmania stage, as well as their cytotoxic effects on murine macrophages (CC50), and in O+ human red blood cells. The data presented in this study showed the potential of an ethyl acetate extract of S. pseudoquina, as well as two flavonoids purified from it, which can be used as a therapeutic alternative on its own, or in association with other drugs, to treat disease evoked by L. amazonensis. |
References: | Exp Parasitol. 2008 Feb;118(2):197-202. (PMID: 17888907) Antimicrob Agents Chemother. 2006 Apr;50(4):1352-64. (PMID: 16569852) Bioorg Med Chem Lett. 2009 May 1;19(9):2585-6. (PMID: 19339182) Antimicrob Agents Chemother. 2005 Jan;49(1):176-82. (PMID: 15616293) Curr Opin Infect Dis. 2003 Oct;16(5):397-401. (PMID: 14501991) J Nat Prod. 1984 Nov-Dec;47(6):953-7. (PMID: 6533269) Antimicrob Agents Chemother. 1999 Sep;43(9):2328-31. (PMID: 10471592) Ann Ist Super Sanita. 1967;3(2):190-2. (PMID: 5618691) Bioorg Med Chem. 2003 May 1;11(9):1995-2000. (PMID: 12670650) Chem Pharm Bull (Tokyo). 2005 Aug;53(8):881-5. (PMID: 16079513) Acta Trop. 2011 May;118(2):87-96. (PMID: 21420925) World Health Organ Tech Rep Ser. 2010;(949):xii-xiii, 1-186, back cover. (PMID: 21485694) Infect Immun. 2003 Jul;71(7):3988-94. (PMID: 12819086) J Med Food. 2011 Jun;14(6):557-62. (PMID: 21554130) Food Chem Toxicol. 2006 Sep;44(9):1585-9. (PMID: 16730111) Biochem Pharmacol. 1999 Sep 1;58(5):759-65. (PMID: 10449184) Expert Rev Anti Infect Ther. 2010 Aug;8(8):919-44. (PMID: 20695748) J Ethnopharmacol. 2004 Dec;95(2-3):393-7. (PMID: 15507365) J Ethnopharmacol. 2003 Aug;87(2-3):253-6. (PMID: 12860318) Clin Microbiol Rev. 1993 Jul;6(3):230-50. (PMID: 8358705) Parasitol Int. 2011 Dec;60(4):357-63. (PMID: 21723957) Phytochemistry. 2003 Oct;64(4):897-901. (PMID: 14559288) Exp Parasitol. 2011 May;128(1):61-7. (PMID: 21320493) Euro Surveill. 2010 Mar 11;15(10):19505. (PMID: 20403308) Top Companion Anim Med. 2009 Nov;24(4):182-8. (PMID: 19945086) Parasitol Today. 1996 Jul;12(7):257-61. (PMID: 15275189) Toxicon. 2004 Sep 15;44(4):405-16. (PMID: 15302523) Molecules. 2009 Jun 30;14(7):2317-36. (PMID: 19633606) Phytomedicine. 2005 Jun;12(6-7):514-35. (PMID: 16008131) J Nat Prod. 2009 Jun;72(6):1069-74. (PMID: 19489596) Trends Parasitol. 2003 Nov;19(11):502-8. (PMID: 14580961) Parasitol Int. 2010 Jun;59(2):154-8. (PMID: 20064628) Antimicrob Agents Chemother. 2001 May;45(5):1349-54. (PMID: 11302794) |
تواريخ الأحداث: | Date Created: 20131107 Date Completed: 20131106 Latest Revision: 20220317 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3806161 |
DOI: | 10.1155/2013/304354 |
PMID: | 24194781 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1741-427X |
---|---|
DOI: | 10.1155/2013/304354 |