دورية أكاديمية
Neuropeptides and hippocampal neurogenesis.
| العنوان: | Neuropeptides and hippocampal neurogenesis. |
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| المؤلفون: | Zaben MJ; Neuroscience and Mental Health Research Institute, Cardiff University, Institute of Psychological Medicine and Clinical Neurosciences, 3rd Floor, Room 3.33, The Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, United Kingdom. Electronic address: zabenm@cardiff.ac.uk., Gray WP |
| المصدر: | Neuropeptides [Neuropeptides] 2013 Dec; Vol. 47 (6), pp. 431-8. Date of Electronic Publication: 2013 Oct 22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8103156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2785 (Electronic) Linking ISSN: 01434179 NLM ISO Abbreviation: Neuropeptides Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Amsterdam : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1980- |
| مواضيع طبية MeSH: | Neurogenesis*, Hippocampus/*physiology , Neuropeptides/*physiology, Animals ; Galanin/physiology ; Hippocampus/embryology ; Hippocampus/growth & development ; Humans ; Learning/physiology ; Memory/physiology ; Mice ; Neuropeptide Y/physiology ; Rats ; Vasoactive Intestinal Peptide/physiology |
| مستخلص: | Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell niche, local interneurons appear to play an important part in this excitation-neurogenesis coupling via GABAergic transmission, which promotes neuronal differentiation and integration. Neuropeptides such as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP) and galanin have emerged as important mediators for signalling local and extrinsic interneuronal activity to subgranular zone precursors. Here we review the distribution of these neuropeptides and their receptors in the neurogenic area of the hippocampus and their precise effects on hippocampal neurogenesis. We also discuss neuropeptides' potential involvement in functional aspects of hippocampal neurogenesis particularly their involvement in the modulation of learning and memory and behavior responses. (Copyright © 2013. Published by Elsevier Ltd.) |
| معلومات مُعتمدة: | G0300356 United Kingdom MRC_ Medical Research Council; G0801418 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Galanin; Hippocampus; NPY and learning and memory; Neurogenesis; VIP |
| المشرفين على المادة: | 0 (Neuropeptide Y) 0 (Neuropeptides) 37221-79-7 (Vasoactive Intestinal Peptide) 88813-36-9 (Galanin) |
| تواريخ الأحداث: | Date Created: 20131113 Date Completed: 20140710 Latest Revision: 20220309 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.npep.2013.10.002 |
| PMID: | 24215800 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2785 |
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| DOI: | 10.1016/j.npep.2013.10.002 |