دورية أكاديمية
A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy.
| العنوان: | A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy. |
|---|---|
| المؤلفون: | Kapur R; Department of Experimental Immunohematology and., Kustiawan I, Vestrheim A, Koeleman CA, Visser R, Einarsdottir HK, Porcelijn L, Jackson D, Kumpel B, Deelder AM, Blank D, Skogen B, Killie MK, Michaelsen TE, de Haas M, Rispens T, van der Schoot CE, Wuhrer M, Vidarsson G |
| المصدر: | Blood [Blood] 2014 Jan 23; Vol. 123 (4), pp. 471-80. Date of Electronic Publication: 2013 Nov 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New York, Grune & Stratton [etc.] |
| مواضيع طبية MeSH: | Blood Platelets/*immunology , Immunoglobulin Fc Fragments/*chemistry , Immunoglobulin G/*chemistry , Isoantibodies/*chemistry , Thrombocytopenia, Neonatal Alloimmune/*blood , Thrombocytopenia, Neonatal Alloimmune/*immunology, Antibodies, Monoclonal/chemistry ; Asparagine/chemistry ; Cohort Studies ; Female ; Fucose/chemistry ; Glucose/chemistry ; Glycosylation ; HLA Antigens/chemistry ; Humans ; Immunoglobulin Fc Fragments/blood ; Immunoglobulin G/blood ; Isoantibodies/blood ; Mass Spectrometry ; Monocytes/cytology ; Platelet Count ; Postpartum Period ; Pregnancy ; Recombinant Proteins/chemistry ; Surface Plasmon Resonance |
| مستخلص: | Immunoglobulin G (IgG) formed during pregnancy against human platelet antigens (HPAs) of the fetus mediates fetal or neonatal alloimmune thrombocytopenia (FNAIT). Because antibody titer or isotype does not strictly correlate with disease severity, we investigated by mass spectrometry variations in the glycosylation at Asn297 in the IgG Fc because the composition of this glycan can be highly variable, affecting binding to phagocyte IgG-Fc receptors (FcγR). We found markedly decreased levels of core fucosylation of anti-HPA-1a-specific IgG1 from FNAIT patients (n = 48), but not in total serum IgG1. Antibodies with a low amount of fucose displayed higher binding affinity to FcγRIIIa and FcγRIIIb, but not to FcγRIIa, compared with antibodies with a high amount of Fc fucose. Consequently, these antibodies with a low amount of Fc fucose showed enhanced phagocytosis of platelets using FcγRIIIb(+) polymorphonuclear cells or FcγRIIIa(+) monocytes as effector cells, but not with FcγRIIIa(-) monocytes. In addition, the degree of anti-HPA-1a fucosylation correlated positively with the neonatal platelet counts in FNAIT, and negatively to the clinical disease severity. In contrast to the FNAIT patients, no changes in core fucosylation were observed for anti-HLA antibodies in refractory thrombocytopenia (post platelet transfusion), indicating that the level of fucosylation may be antigen dependent and/or related to the immune milieu defined by pregnancy. |
| التعليقات: | Comment in: Blood. 2014 Jan 23;123(4):463-4. (PMID: 24458274) |
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| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (HLA Antigens) 0 (Immunoglobulin Fc Fragments) 0 (Immunoglobulin G) 0 (Isoantibodies) 0 (Recombinant Proteins) 28RYY2IV3F (Fucose) 7006-34-0 (Asparagine) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20131119 Date Completed: 20140319 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3901064 |
| DOI: | 10.1182/blood-2013-09-527978 |
| PMID: | 24243971 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1528-0020 |
|---|---|
| DOI: | 10.1182/blood-2013-09-527978 |