دورية أكاديمية
أعرض في EDS

Role of histamine as a toxic mediator in the pathogenesis of vitiligo.

التفاصيل البيبلوغرافية
العنوان: Role of histamine as a toxic mediator in the pathogenesis of vitiligo.
المؤلفون: Panja SK; Department of Dermatology, S S K M Hospital and Institute of Post-Graduate Medical Education and Research, Kolkata, India., Bhattacharya B, Lahiri SC
المصدر: Indian journal of dermatology [Indian J Dermatol] 2013 Nov; Vol. 58 (6), pp. 421-8.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 0370750 Publication Model: Print Cited Medium: Internet ISSN: 1998-3611 (Electronic) Linking ISSN: 00195154 NLM ISO Abbreviation: Indian J Dermatol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: Calcutta : Indian Association of Dermatologists, Venerologists and Leprologists, West Bengal Branch.
مستخلص: Background: The precise cause of vitiligo is still unclear. Multiple theories have been proposed, including genetic, autoimmune, neural, and biochemical mechanisms. An immune mediated pathogenesis is indeed the most popular theory. The autoimmune hypothesis considers the role of toxic mediator that might cause an injury to the melanocytes with the release of an antigenic substance and subsequent autoimmunization.
Aims: This study performed over a period of 10 years (February 1975 to June 1985) aims at exploring the role that histamine might play in the pathogenesis of vitiligo.
Materials and Methods: Fifty patients with a particular type of vitiligo characterized by faint white patches occurring with significant pruritus and a history of atopy were selected and blood histamine levels were determined by Bio-Assay method.
Results: Blood histamine values of patients with vitiligo of short duration and with pruritus were significantly increased in comparison with values of matched controls.
Conclusion: Histamine appears to play a significant role in the pathogenesis of a particular type of vitiligo characterized by faint hypopigmented patches with significant itching.
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فهرسة مساهمة: Keywords: Autoimmunity; atopy; histamine; intolerance to melanizing agents; vitiligo
تواريخ الأحداث: Date Created: 20131120 Date Completed: 20131119 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3827511
DOI: 10.4103/0019-5154.119947
PMID: 24249891
قاعدة البيانات: MEDLINE
الوصف
تدمد:1998-3611
DOI:10.4103/0019-5154.119947