دورية أكاديمية
Prevalence, clinical characteristics and outcome of pulmonary hypertension among admitted heart failure patients.
| العنوان: | Prevalence, clinical characteristics and outcome of pulmonary hypertension among admitted heart failure patients. |
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| المؤلفون: | Karaye KM; Department of Medicine; Bayero University; Aminu Kano Teaching Hospital, PMB 3452, Kano, Nigeria., Saidu H, Bala MS, Yahaya IA |
| المصدر: | Annals of African medicine [Ann Afr Med] 2013 Oct-Dec; Vol. 12 (4), pp. 197-204. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 101231417 Publication Model: Print Cited Medium: Internet ISSN: 0975-5764 (Electronic) Linking ISSN: 09755764 NLM ISO Abbreviation: Ann Afr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mumbai, India : Medknow Publications Original Publication: Sokoto, Nigeria : [Zaria, Nigeria?] : Usmanu Danfodiyo University Teaching Hospital ; Annals of African Medicine Society |
| مواضيع طبية MeSH: | Heart Failure/*mortality , Hypertension, Pulmonary/*mortality, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Echocardiography, Doppler ; Female ; Heart Failure/complications ; Heart Failure/physiopathology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Hospital Mortality ; Humans ; Hypertension/complications ; Hypertension/mortality ; Hypertension, Pulmonary/diagnostic imaging ; Hypertension, Pulmonary/etiology ; Inpatients ; Male ; Middle Aged ; Nigeria ; Prevalence ; Prospective Studies ; Survival Rate ; Ventricular Function, Left ; Young Adult |
| مستخلص: | Background: There is paucity of data in Africa on the prevalence of pulmonary hypertension (PHT) and its impact on morbidity and short-term mortality in heart failure (HF) patients. The aim of this study was to assess the prevalence of PHT, its clinical characteristics and in-hospital mortality among HF patients admitted to a referral hospital in Nigeria. Methods: The study was carried out on serially-admitted HF patients who satisfied the inclusion criteria, in a Nigerian tertiary health center. PHT was defined as the presence of mean pulmonary artery pressure (mPAP) of ≥25 mmHg, assessed using Doppler echocardiography and Chemla formula. Results: A total of 80 admitted HF patients were studied serially. 53 of them (66.25%) had PHT while the remaining 27 (33.75%) had normal mPAP. mPAP was 38.31 ± 12.23 mmHg and 16.39 ± 5.48 mmHg (P < 0.001) for subjects with and without PHT, respectively. The most common cause of HF was hypertensive heart disease (HHD) (28 patients; 35%). Subjects with PHT had relatively lower systolic blood pressure (SBP) (P = 0.044), and larger left atrium (P = 0.036) and left ventricle (LV) at both end-diastole and end-systole (P = 0.036 and P = 0.008, respectively), and a trend toward lower LV ejection fraction (LVEF) (P = 0.053). There was no relationship between mPAP and N-terminal pro-B type natriuretic peptide (P > 0.05). A total of 12 HF patients (15.0%) died, out of whom 8 (66.7%) had PHT. Cardiogenic shock (P = 0.044) and trans-mitral flow velocities ratio (P = 0.023) were the independent determinants of in-hospital mortality. Conclusion: PHT was common among the admitted HF patients, and was associated with worse morbidity indices, and a trend toward higher mortality. We recommend that HF patients be screened for PHT, and its presence should be taken into consideration in the management and prognostication of affected patients. |
| تواريخ الأحداث: | Date Created: 20131207 Date Completed: 20140212 Latest Revision: 20161128 |
| رمز التحديث: | 20221213 |
| DOI: | 10.4103/1596-3519.122685 |
| PMID: | 24309407 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0975-5764 |
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| DOI: | 10.4103/1596-3519.122685 |