دورية أكاديمية
أعرض في EDS

Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty?

التفاصيل البيبلوغرافية
العنوان: Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty?
المؤلفون: Henriksen VT; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Rogers VE; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Rasmussen GL; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Trawick RH; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Momberger NG; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Aguirre D; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Barker T; The Orthopedic Specialty Hospital, Murray, UT 84107, USA. Electronic address: tyler.barker@imail.org.
المصدر: Medical hypotheses [Med Hypotheses] 2014 Feb; Vol. 82 (2), pp. 134-7. Date of Electronic Publication: 2013 Dec 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Eden Press Country of Publication: United States NLM ID: 7505668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2777 (Electronic) Linking ISSN: 03069877 NLM ISO Abbreviation: Med Hypotheses Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Elsevier, 2002- : Eden Press
Original Publication: Penrith, Eng., Eden Press.
مواضيع طبية MeSH: Arthroplasty, Replacement, Knee/*adverse effects , Vitamin D/*analogs & derivatives, C-Reactive Protein/metabolism ; Cytokines/metabolism ; Female ; Humans ; Inflammation ; Luminescence ; Middle Aged ; Models, Theoretical ; Postoperative Period ; Treatment Outcome ; Vitamin D/blood ; Vitamin D Deficiency/complications
مستخلص: Vitamin D is a fat-soluble micronutrient that regulates inflammation and skeletal muscle size and function. Inflammation and skeletal muscle dysfunction (i.e., atrophy and weakness) are predominant impairments that continue to challenge the rehabilitation from total knee arthroplasty (TKA). Data suggest a decrease in serum 25-hydroxyvitamin D (25(OH)D) concentrations after TKA. Despite the decrease being attributed to a systemic inflammatory response, it is unclear what inflammatory mediator(s) is contributing to the decrease in serum 25(OH)D concentrations after TKA. In immune cells, pro-inflammatory cytokines mediate the enzymatic conversion of 25(OH)D to 1,25-dihydroxyvitamin D, implying that pro-inflammatory cytokines contribute to the decrease in substrate availability (i.e., 25(OH)D). We propose the hypothesis that pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after TKA. To complement the supporting literature for the proposed hypothesis, we analyzed serum 25(OH)D and pro-inflammatory cytokine concentrations prior to and serially after TKA in a case subject (female; age, 62 year; height, 160 cm; body mass, 63 kg; body mass index, 26.5 kg/m(2)). The subtle decrease (12%) from pre-surgery to 2-d post-surgery and the more pronounced decrease (74%) from 3-week to 8-week post-surgery in serum 25(OH)D concentrations corresponded with the increase in serum pro-inflammatory cytokine (i.e., TNF-α, IFN-γ, IL-1β, GM-CSF, and IL-6) concentrations. This observation lends credence to the proposed hypothesis that pro-inflammatory cytokines could contribute to the decrease in serum 25(OH)D concentrations after TKA. Clearly, future research is needed to confirm the proposed hypothesis and to identify if attenuating the decrease in serum 25(OH)D concentrations improves patient outcomes after TKA.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
المشرفين على المادة: 0 (Cytokines)
1406-16-2 (Vitamin D)
9007-41-4 (C-Reactive Protein)
A288AR3C9H (25-hydroxyvitamin D)
تواريخ الأحداث: Date Created: 20131217 Date Completed: 20140929 Latest Revision: 20180813
رمز التحديث: 20231215
DOI: 10.1016/j.mehy.2013.11.020
PMID: 24332533
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-2777
DOI:10.1016/j.mehy.2013.11.020