دورية أكاديمية
Prokaryotic ancestry of eukaryotic protein networks mediating innate immunity and apoptosis.
| العنوان: | Prokaryotic ancestry of eukaryotic protein networks mediating innate immunity and apoptosis. |
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| المؤلفون: | Dunin-Horkawicz S; Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany. Electronic address: sdh@genesilico.pl., Kopec KO; Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany., Lupas AN; Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany. Electronic address: andrei.lupas@tuebingen.mpg.de. |
| المصدر: | Journal of molecular biology [J Mol Biol] 2014 Apr 03; Vol. 426 (7), pp. 1568-82. Date of Electronic Publication: 2013 Dec 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: 1959- : London : Academic Press |
| مواضيع طبية MeSH: | Apoptosis/*physiology , Immunity, Innate/*physiology , Proteins/*chemistry , Proteins/*genetics, Amino Acid Sequence ; Apoptosis/genetics ; Computational Biology ; Eukaryotic Cells/cytology ; Eukaryotic Cells/metabolism ; Immunity, Innate/genetics ; Molecular Sequence Data ; Prokaryotic Cells/cytology ; Prokaryotic Cells/metabolism ; Sequence Homology, Amino Acid |
| مستخلص: | Protein domains characteristic of eukaryotic innate immunity and apoptosis have many prokaryotic counterparts of unknown function. By reconstructing interactomes computationally, we found that bacterial proteins containing these domains are part of a network that also includes other domains not hitherto associated with immunity. This network is connected to the network of prokaryotic signal transduction proteins, such as histidine kinases and chemoreceptors. The network varies considerably in domain composition and degree of paralogy, even between strains of the same species, and its repetitive domains are often amplified recently, with individual repeats sharing up to 100% sequence identity. Both phenomena are evidence of considerable evolutionary pressure and thus compatible with a role in the "arms race" between host and pathogen. In order to investigate the relationship of this network to its eukaryotic counterparts, we performed a cluster analysis of organisms based on a census of its constituent domains across all fully sequenced genomes. We obtained a large central cluster of mainly unicellular organisms, from which multicellular organisms radiate out in two main directions. One is taken by multicellular bacteria, primarily cyanobacteria and actinomycetes, and plants form an extension of this direction, connected via the basal, unicellular cyanobacteria. The second main direction is taken by animals and fungi, which form separate branches with a common root in the α-proteobacteria of the central cluster. This analysis supports the notion that the innate immunity networks of eukaryotes originated from their endosymbionts and that increases in the complexity of these networks accompanied the emergence of multicellularity. (Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: comparative genomics; endosymbiosis; innate immunity; molecular evolution; protein networks |
| المشرفين على المادة: | 0 (Proteins) |
| تواريخ الأحداث: | Date Created: 20131217 Date Completed: 20140502 Latest Revision: 20140310 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jmb.2013.11.030 |
| PMID: | 24333018 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1089-8638 |
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| DOI: | 10.1016/j.jmb.2013.11.030 |