دورية أكاديمية
Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities.
| العنوان: | Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities. |
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| المؤلفون: | Luo CT; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China., Zheng HH; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China., Mao SS; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China., Yang MX; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China., Luo C; State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China., Chen H; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China. |
| المصدر: | Planta medica [Planta Med] 2014 Feb; Vol. 80 (2-3), pp. 201-8. Date of Electronic Publication: 2013 Dec 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0221 (Electronic) Linking ISSN: 00320943 NLM ISO Abbreviation: Planta Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart ; New York : George Thieme Original Publication: Stuttgart, Hippokrates Verlag. |
| مواضيع طبية MeSH: | Glycoside Hydrolases/*antagonists & inhibitors , Plant Extracts/*pharmacology , Swertia/*chemistry , Xanthones/*pharmacology, Nuclear Magnetic Resonance, Biomolecular ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Software ; Xanthones/chemistry ; Xanthones/isolation & purification |
| مستخلص: | Two new xanthones, 1,8-dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 2)-β-D-glucopyranoside] (1) and 1,8- dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 3)-α-L-rhamno-pyranosyl (1 → 2)-β-D-xylopyranoside] (2), together with 26 known xanthones (3-28), were isolated from the aqueous ethanol extract of the traditional Chinese herb Swertia mussotii. Their structures were elucidated via spectroscopic analyses including 2D NMR. The inhibition of α-glucosidase by the isolated xanthones was evaluated by an in vitro high-throughput screening assay. Our results indicated that 1,3,5,8-tetrahydroxyxanthone is the best inhibitor with an IC50 value of 5.33 ± 0.09 µM, while the O-glycosylated xanthones were poor α-glycosidase inhibitors. (Georg Thieme Verlag KG Stuttgart · New York.) |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Xanthones) EC 3.2.1.- (Glycoside Hydrolases) |
| تواريخ الأحداث: | Date Created: 20131221 Date Completed: 20141107 Latest Revision: 20140217 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1055/s-0033-1360173 |
| PMID: | 24356906 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-0221 |
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| DOI: | 10.1055/s-0033-1360173 |