دورية أكاديمية
Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats.
| العنوان: | Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats. |
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| المؤلفون: | Zhang X; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China., Wu B; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China., Nie K; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China., Jia Y; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China., Yu J; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: zhangxuezhu1999@126.com. |
| المصدر: | Neurochemistry international [Neurochem Int] 2014 Jan; Vol. 65, pp. 23-9. Date of Electronic Publication: 2013 Dec 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford [Elmsford, N. Y.] Pergamon Press. |
| مواضيع طبية MeSH: | Acupuncture Therapy*, Cerebrovascular Circulation/*physiology , Cognition/*physiology , Dementia, Multi-Infarct/*therapy , Mitochondria/*metabolism , Oxidative Stress/*physiology, Animals ; Dementia, Multi-Infarct/metabolism ; Disease Models, Animal ; Male ; Rats ; Rats, Wistar |
| مستخلص: | Brain energy disorders and oxidative stress due to chronic hypoperfusion were considered to be the major risk factors in the pathogenesis of dementia. In previous studies, we have demonstrated that acupuncture treatment improved cognitive function of VaD patients and multi-infarct dementia (MID) rats. Acupuncture therapy also increased the activities of glycometabolic enzymes in the brain. But it is not clear whether acupuncture treatment compensates neuronal energy deficit after cerebral ischemic through enhancing the activities of glucose metabolic enzymes and preserving mitochondrial function, and whether acupuncture neuroprotective effect is associated with activations of mitochondrial antioxidative defense system. So, the effect of acupuncture therapy on cognitive function, cerebral blood flow (CBF), mitochondrial respiratory function and oxidative stress in the brain of MID rats was investigated in this study. The results showed that acupuncture treatment significantly improved cognitive abilities and increased regional CBF of MID rats. Acupuncture elevated the activities of total SOD, CuZnSOD and MnSOD, decreased the level of malondialdehyde (MDA) and superoxide anion, regulated the ratio of reduced glutathione (GSH) and oxidized glutathione (GSSG) in mitochondria, and raised the level of the respiratory control index (RCI) and P/O ratio and the activities of mitochondrial respiratory enzymes of MID rats. These results indicated that acupuncture treatment improved cognitive function of MID rats; and this improvement might be due to increased CBF, which ameliorated mitochondrial dysfunction induced by ischemia and endogenous oxidative stress system of brain. (Copyright © 2013 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acupuncture; Cerebral blood flow; Mitochondrial respiration; Oxidative stress; Vascular dementia |
| تواريخ الأحداث: | Date Created: 20131224 Date Completed: 20141020 Latest Revision: 20140205 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.neuint.2013.12.004 |
| PMID: | 24361538 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-9754 |
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| DOI: | 10.1016/j.neuint.2013.12.004 |