دورية أكاديمية
أعرض في EDS

Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring.

التفاصيل البيبلوغرافية
العنوان: Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring.
المؤلفون: Abdul Rahman A; Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, Malaysia., Abdul Karim N; Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, Malaysia., Abdul Hamid NA; Cyberjaya University College of Medical Sciences, 63000 Cyberjaya, Selangor, Malaysia., Harun R; UKM Medical Molecular Biology Institute (UMBI), UKM Hospital, Level 7, Clinical Block, Cheras, 56000 Kuala Lumpur, Malaysia., Ngah WZ; Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, Malaysia ; UKM Medical Molecular Biology Institute (UMBI), UKM Hospital, Level 7, Clinical Block, Cheras, 56000 Kuala Lumpur, Malaysia.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2013; Vol. 2013, pp. 189129. Date of Electronic Publication: 2013 Nov 27.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Gene Expression Regulation*, Cellular Senescence/*genetics , Leukocytes, Mononuclear/*cytology , Leukocytes, Mononuclear/*metabolism, Aged, 80 and over ; Cluster Analysis ; Female ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Reproducibility of Results
مستخلص: Mechanisms determining both functional rate of decline and the time of onset in aging remain elusive. Studies of the aging process especially those involving the comparison of long-lived individuals and young controls are fairly limited. Therefore, this research aims to determine the differential gene expression profile in related individuals from villages in Pahang, Malaysia. Genome-wide microarray analysis of 18 samples of peripheral blood mononuclear cells (PBMCs) from two groups: octo/nonagenarians (80-99 years old) and their offspring (50.2 ± 4.0 years old) revealed that 477 transcripts were age-induced and 335 transcripts were age-repressed with fold changes ≥1.2 in octo/nonagenarians compared to offspring. Interestingly, changes in gene expression were associated with increased capacity for apoptosis (BAK1), cell cycle regulation (CDKN1B), metabolic process (LRPAP1), insulin action (IGF2R), and increased immune and inflammatory response (IL27RA), whereas response to stress (HSPA8), damage stimulus (XRCC6), and chromatin remodelling (TINF2) pathways were downregulated in octo/nonagenarians. These results suggested that systemic telomere maintenance, metabolism, cell signalling, and redox regulation may be important for individuals to maintain their healthy state with advancing age and that these processes play an important role in the determination of the healthy life-span.
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تواريخ الأحداث: Date Created: 20140102 Date Completed: 20140715 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3863454
DOI: 10.1155/2013/189129
PMID: 24381713
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2013/189129