دورية أكاديمية
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The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B.

التفاصيل البيبلوغرافية
العنوان: The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B.
المؤلفون: Tsang KH; 1] Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., Lai SK; 1] Department of Physiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., Li Q; 1] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Department of Psychiatry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., Yung WH; School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong, China., Liu H; 1] Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., Mak PH; 1] Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., Ng CC; 1] Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., McAlonan G; 1] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Department of Psychiatry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [3] Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, United Kingdom., Chan YS; 1] Department of Physiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China., Chan SY; 1] Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China [2] Centre for Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China.
المصدر: Scientific reports [Sci Rep] 2014 Jan 13; Vol. 4, pp. 3654. Date of Electronic Publication: 2014 Jan 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Gene Expression Regulation*, Nuclear Proteins/*metabolism , Receptors, N-Methyl-D-Aspartate/*genetics, Animals ; DNA-Binding Proteins ; Fear ; Female ; Hippocampus/metabolism ; Learning ; Long-Term Potentiation/genetics ; Male ; Memory ; Mice ; Mutation ; Nuclear Proteins/genetics ; Pyramidal Cells/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Transcriptional Activation
مستخلص: TSPYL2 is an X-linked gene encoding a nucleosome assembly protein. TSPYL2 interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked mental retardation. As nucleosome assembly and chromatin remodeling are important in transcriptional regulation and neuronal function, we addressed the importance of TSPYL2 through analyzing Tspyl2 loss-of-function mice. We detected down-regulation of N-methyl-D-aspartate receptor subunits 2A and 2B (GluN2A and GluN2B) in the mutant hippocampus. Evidence from luciferase reporter assays and chromatin immunoprecipitation supported that TSPYL2 regulated the expression of Grin2a and Grin2b, the genes encoding GluN2A and GluN2B. We also detected an interaction between TSPYL2 and CBP, indicating that TSPYL2 may activate gene expression through binding CBP. In terms of functional outcome, Tspyl2 loss-of-function impaired long-term potentiation at hippocampal Schaffer collateral-CA1 synapses. Moreover, mutant mice showed a deficit in fear learning and memory. We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a and Grin2b.
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معلومات مُعتمدة: United Kingdom Medical Research Council
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (NR2B NMDA receptor)
0 (Nuclear Proteins)
0 (Receptors, N-Methyl-D-Aspartate)
0 (TSPYL2 protein, human)
VH92ICR8HX (N-methyl D-aspartate receptor subtype 2A)
تواريخ الأحداث: Date Created: 20140114 Date Completed: 20150730 Latest Revision: 20211203
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3888966
DOI: 10.1038/srep03654
PMID: 24413569
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep03654