دورية أكاديمية
أعرض في EDS

β3-chimaerin, a novel member of the chimaerin Rac-GAP family.

التفاصيل البيبلوغرافية
العنوان: β3-chimaerin, a novel member of the chimaerin Rac-GAP family.
المؤلفون: Zubeldia-Brenner L; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, IQUIBICEN-CONICET, Universidad de Buenos Aires, C1428EGA, Buenos Aires, Argentina., Gutierrez-Uzquiza A, Barrio-Real L, Wang H, Kazanietz MG, Leskow FC
المصدر: Molecular biology reports [Mol Biol Rep] 2014; Vol. 41 (4), pp. 2067-76. Date of Electronic Publication: 2014 Jan 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Dordrecht, Boston, Reidel.
مواضيع طبية MeSH: Protein Isoforms*, Chimerin Proteins/*genetics , Chimerin Proteins/*metabolism, Alternative Splicing ; Amino Acid Sequence ; Animals ; Base Sequence ; COS Cells ; Cell Line ; Chimerin Proteins/chemistry ; Chlorocebus aethiops ; Enzyme Activation ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Gene Order ; Humans ; Molecular Sequence Data ; Organ Specificity/genetics ; Promoter Regions, Genetic ; Protein Binding ; Protein Interaction Domains and Motifs ; Tetradecanoylphorbol Acetate/pharmacology ; rac GTP-Binding Proteins/metabolism
مستخلص: Chimaerins are a family of diacylglycerol- and phorbol ester-regulated GTPase activating proteins (GAPs) for the small G-protein Rac. Extensive evidence indicates that these proteins play important roles in development, axon guidance, metabolism, cell motility, and T cell activation. Four isoforms have been reported to-date, which are products of CHN1 (α1- and α2-chimaerins) and CHN2 (β1- and β2-chimaerins) genes. Although these gene products are assumed to be generated by alternative splicing, bioinformatics analysis of the CHN2 gene revealed that β1- and β2-chimaerins are the products of alternative transcription start sites (TSSs) in different promoter regions. Furthermore, we found an additional TSS in CHN2 gene that leads to a novel product, which we named β3-chimaerin. Expression profile analysis revealed predominantly low levels for the β3-chimaerin transcript, with higher expression levels in epididymis, plasma blood leucocytes, spleen, thymus, as well as various areas of the brain. In addition to the prototypical SH2, C1, and Rac-GAP domains, β3-chimaerin has a unique N-terminal domain. Studies in cells established that β3-chimaerin has Rac-GAP activity and is responsive to phorbol esters. The enhanced responsiveness of β3-chimaerin for phorbol ester-induced translocation relative to β2-chimaerin suggests differential ligand accessibility to the C1 domain.
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معلومات مُعتمدة: R01 CA074197 United States CA NCI NIH HHS; R01 CA139120 United States CA NCI NIH HHS; R01-CA74197 United States CA NCI NIH HHS; R01-CA139120 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Chimerin Proteins)
0 (Protein Isoforms)
0 (chimaerin-beta3 protein, human)
EC 3.6.5.2 (rac GTP-Binding Proteins)
NI40JAQ945 (Tetradecanoylphorbol Acetate)
تواريخ الأحداث: Date Created: 20140117 Date Completed: 20141203 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3969763
DOI: 10.1007/s11033-014-3055-3
PMID: 24430297
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-4978
DOI:10.1007/s11033-014-3055-3