دورية أكاديمية
Fat & fabulous: bifunctional lipids in the spotlight.
| العنوان: | Fat & fabulous: bifunctional lipids in the spotlight. |
|---|---|
| المؤلفون: | Haberkant P; European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address: per.haberkant@embl.de., Holthuis JC; Molecular Cell Biology, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany. Electronic address: joost.holthuis@biologie.uni-osnabrueck.de. |
| المصدر: | Biochimica et biophysica acta [Biochim Biophys Acta] 2014 Aug; Vol. 1841 (8), pp. 1022-30. Date of Electronic Publication: 2014 Jan 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-3002 (Print) Linking ISSN: 00063002 NLM ISO Abbreviation: Biochim Biophys Acta Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Pub. Co. |
| مواضيع طبية MeSH: | Lipids/*physiology, Lipids/chemistry ; Photochemical Processes ; Proteins/chemistry |
| مستخلص: | Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as membrane lipids have rarely been studied in large-scale interaction screens. Here, we review the development of photoactivatable and clickable lipid analogues-so-called bifunctional lipids-as novel chemical tools that enable a global profiling of lipid-protein interactions in biological membranes. Recent studies indicate that bifunctional lipids hold great promise in systematic efforts to dissect the elaborate crosstalk between proteins and lipids in live cells and organisms. This article is part of a Special Issue entitled Tools to study lipid functions. (Copyright © 2014 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Click chemistry; Imaging; Photoaffinity labeling; Protein–lipid interaction; Proteomics |
| المشرفين على المادة: | 0 (Lipids) 0 (Proteins) |
| تواريخ الأحداث: | Date Created: 20140121 Date Completed: 20140820 Latest Revision: 20161126 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.bbalip.2014.01.003 |
| PMID: | 24440797 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0006-3002 |
|---|---|
| DOI: | 10.1016/j.bbalip.2014.01.003 |