دورية أكاديمية
أعرض في EDS

Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.

التفاصيل البيبلوغرافية
العنوان: Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.
المؤلفون: Thorek DL; 1] Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins School of Medicine, 601 N. Caroline Street, JHOC 3223, Baltimore, Maryland 21287, USA [2] Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA., Ulmert D; 1] Department of Surgery, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA [2] Department of Urology, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden., Diop NF; Department of Biomedical Engineering, The City College of New York, ST-401, 160 Convent Avenue, New York, New York 10031, USA., Lupu ME; Department of Medical Physics, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA., Doran MG; Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA., Huang R; Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA., Abou DS; Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins School of Medicine, 601 N. Caroline Street, JHOC 3223, Baltimore, Maryland 21287, USA., Larson SM; 1] Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA [2] Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA., Grimm J; 1] Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA [2] Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center (MSKCC), 1275 York Street, Box 248, New York, New York 10065, USA.
المصدر: Nature communications [Nat Commun] 2014; Vol. 5, pp. 3097.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Magnetic Resonance Imaging* , Multimodal Imaging* , Nanoparticles*/administration & dosage , Positron-Emission Tomography*, Lymph Nodes/*diagnostic imaging, Animals ; Disease Models, Animal ; Drainage ; Ferrosoferric Oxide/administration & dosage ; Genetic Engineering ; Lymph Nodes/surgery ; Male ; Mice, Transgenic ; Prostatic Neoplasms/diagnostic imaging
مستخلص: The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, (89)Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that (89)Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.
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معلومات مُعتمدة: P50 CA086438 United States CA NCI NIH HHS; R25 CA096945 United States CA NCI NIH HHS; P30 CA08748 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; R24 CA83084 United States CA NCI NIH HHS; 5R25CA096945-07 United States CA NCI NIH HHS; R01 EB014944 United States EB NIBIB NIH HHS; R24 CA083084 United States CA NCI NIH HHS; 1R01EB014944-01 United States EB NIBIB NIH HHS
المشرفين على المادة: XM0M87F357 (Ferrosoferric Oxide)
تواريخ الأحداث: Date Created: 20140122 Date Completed: 20151027 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4080716
DOI: 10.1038/ncomms4097
PMID: 24445347
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/ncomms4097