دورية أكاديمية
أعرض في EDS

CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria.

التفاصيل البيبلوغرافية
العنوان: CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria.
المؤلفون: Gitau EN; KEMRI-Wellcome Trust Collaborative Programme, Centre for Geographic Medicine Coast, 80108 Kilifi, Kenya;, Tuju J, Karanja H, Stevenson L, Requena P, Kimani E, Olotu A, Kimani D, Marsh K, Bull P, Urban BC
المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Feb 15; Vol. 192 (4), pp. 1753-61. Date of Electronic Publication: 2014 Jan 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Bethesda, MD : American Association of Immunologists
Original Publication: Baltimore : Williams & Wilkins, c1950-
مواضيع طبية MeSH: Antibodies, Protozoan/*immunology , CD4-Positive T-Lymphocytes/*immunology , Malaria, Falciparum/*immunology , Protozoan Proteins/*immunology, Antigens, Protozoan/immunology ; Child ; Child, Preschool ; Cohort Studies ; Erythrocytes/immunology ; Erythrocytes/parasitology ; Female ; Humans ; Interferon-gamma/metabolism ; Interleukin-4/metabolism ; Kenya ; Male ; Molecular Sequence Data ; Plasmodium falciparum/immunology ; Protein Structure, Tertiary
مستخلص: The immune response against the variant surface Ag Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key component of clinical immunity against malaria. We have investigated the development and maintenance of CD4(+) T cell responses to a small semiconserved area of the Duffy binding-like domain (DBL)α-domain of PfEMP1, the DBLα-tag. Young children were followed up longitudinally, and parasites and PBMCs were isolated from 35 patients presenting with an acute case of uncomplicated malaria. The DBLα-tag from the PfEMP1 dominantly expressed by the homologous parasite isolate was cloned and expressed as recombinant protein. The recombinant DBLα-tag was used to activate PBMCs collected from each acute episode and from an annual cross-sectional survey performed after the acute malaria episode. In this article, we report that CD4(+) T cell responses to the homologous DBLα-tag were induced in 75% of the children at the time of the acute episode and in 62% of the children at the following cross-sectional survey on average 235 d later. Furthermore, children who had induced DBLα-tag-specific CD4(+)IL-4(+) T cells at the acute episode remained episode free for longer than children who induced other types of CD4(+) T cell responses. These results suggest that a wide range of DBLα-tag-specific CD4(+) T cell responses were induced in children with mild malaria and, in the case of CD4(+)IL-4(+) T cell responses, were associated with protection from clinical episodes.
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معلومات مُعتمدة: 084535 United Kingdom WT_ Wellcome Trust; 084538 United Kingdom WT_ Wellcome Trust; United Kingdom Wellcome Trust; 079082 United Kingdom Wellcome Trust; 077176 United Kingdom WT_ Wellcome Trust; 092654 United Kingdom Wellcome Trust
فهرسة مساهمة: Indexing Agency: NLM Local ID #: EMS56059.
سلسلة جزيئية: GENBANK HE863905; HE863906; HE863907; HE863908; HE863909; HE863910; HE863911; HE863912; HE863913; HE863914; HE863915; HE863916; HE863917; HE863918; HE863919; HE863920; HE863921; HE863922; HE863923; HE863924; HE863925; HE863926; HE863927; HE863928; HE863929; HE863930; HE863931; HE863932; HE863933; HE863934; HE863935; HE863936; HE863937; HE863938; HE863939; HE863940
المشرفين على المادة: 0 (Antibodies, Protozoan)
0 (Antigens, Protozoan)
0 (IL4 protein, human)
0 (Protozoan Proteins)
0 (erythrocyte membrane protein 1, Plasmodium falciparum)
207137-56-2 (Interleukin-4)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20140124 Date Completed: 20140414 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3918862
DOI: 10.4049/jimmunol.1200547
PMID: 24453249
قاعدة البيانات: MEDLINE
الوصف
تدمد:1550-6606
DOI:10.4049/jimmunol.1200547