دورية أكاديمية
CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria.
العنوان: | CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria. |
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المؤلفون: | Gitau EN; KEMRI-Wellcome Trust Collaborative Programme, Centre for Geographic Medicine Coast, 80108 Kilifi, Kenya;, Tuju J, Karanja H, Stevenson L, Requena P, Kimani E, Olotu A, Kimani D, Marsh K, Bull P, Urban BC |
المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Feb 15; Vol. 192 (4), pp. 1753-61. Date of Electronic Publication: 2014 Jan 22. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
مواضيع طبية MeSH: | Antibodies, Protozoan/*immunology , CD4-Positive T-Lymphocytes/*immunology , Malaria, Falciparum/*immunology , Protozoan Proteins/*immunology, Antigens, Protozoan/immunology ; Child ; Child, Preschool ; Cohort Studies ; Erythrocytes/immunology ; Erythrocytes/parasitology ; Female ; Humans ; Interferon-gamma/metabolism ; Interleukin-4/metabolism ; Kenya ; Male ; Molecular Sequence Data ; Plasmodium falciparum/immunology ; Protein Structure, Tertiary |
مستخلص: | The immune response against the variant surface Ag Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key component of clinical immunity against malaria. We have investigated the development and maintenance of CD4(+) T cell responses to a small semiconserved area of the Duffy binding-like domain (DBL)α-domain of PfEMP1, the DBLα-tag. Young children were followed up longitudinally, and parasites and PBMCs were isolated from 35 patients presenting with an acute case of uncomplicated malaria. The DBLα-tag from the PfEMP1 dominantly expressed by the homologous parasite isolate was cloned and expressed as recombinant protein. The recombinant DBLα-tag was used to activate PBMCs collected from each acute episode and from an annual cross-sectional survey performed after the acute malaria episode. In this article, we report that CD4(+) T cell responses to the homologous DBLα-tag were induced in 75% of the children at the time of the acute episode and in 62% of the children at the following cross-sectional survey on average 235 d later. Furthermore, children who had induced DBLα-tag-specific CD4(+)IL-4(+) T cells at the acute episode remained episode free for longer than children who induced other types of CD4(+) T cell responses. These results suggest that a wide range of DBLα-tag-specific CD4(+) T cell responses were induced in children with mild malaria and, in the case of CD4(+)IL-4(+) T cell responses, were associated with protection from clinical episodes. |
References: | J Infect Dis. 2009 Nov 15;200(10):1530-9. (PMID: 19835477) Genes Immun. 2001 Nov;2(7):411-4. (PMID: 11704810) Proc Natl Acad Sci U S A. 2012 May 22;109(21):8247-52. (PMID: 22566630) Malar J. 2012 Jul 16;11:230. (PMID: 22799500) Infect Immun. 2002 Mar;70(3):1468-74. (PMID: 11854234) Malar J. 2005 Apr 27;4:21. (PMID: 15857512) Immunol Lett. 2000 Feb 1;71(2):117-26. (PMID: 10714439) J Exp Med. 2009 May 11;206(5):1001-7. (PMID: 19380638) J Immunol. 2010 Jul 1;185(1):190-202. (PMID: 20525889) Clin Diagn Lab Immunol. 2002 Mar;9(2):348-51. (PMID: 11874876) J Immunol. 1998 Jul 1;161(1):347-59. (PMID: 9647243) Microbes Infect. 2005 Jan;7(1):110-7. (PMID: 15716067) Br J Haematol. 2011 Sep;154(6):670-9. (PMID: 21623767) PLoS Comput Biol. 2010 Sep 16;6(9):. (PMID: 20862303) PLoS Pathog. 2005 Nov;1(3):e26. (PMID: 16304608) J Immunol. 2005 Dec 15;175(12):7867-79. (PMID: 16339522) J Infect Dis. 2012 May 15;205(10):1593-600. (PMID: 22448008) J Immunol. 2002 Oct 15;169(8):4298-306. (PMID: 12370361) PLoS Negl Trop Dis. 2008 Feb 06;2(1):e164. (PMID: 18265875) Mol Microbiol. 2003 Mar;47(5):1265-78. (PMID: 12603733) PLoS One. 2012;7(1):e30095. (PMID: 22272280) Clin Exp Immunol. 2001 Dec;126(3):503-10. (PMID: 11737069) Annu Rev Immunol. 2011;29:621-63. (PMID: 21314428) Mol Biochem Parasitol. 2006 Dec;150(2):211-8. (PMID: 16996149) PLoS Pathog. 2011 Feb 10;7(2):e1001281. (PMID: 21347351) Infect Immun. 1994 Jun;62(6):2490-8. (PMID: 8188374) Annu Rev Immunol. 1994;12:881-922. (PMID: 7516669) J Immunol. 1996 Apr 1;156(7):2510-6. (PMID: 8786312) J Infect Dis. 1999 Jan;179(1):209-16. (PMID: 9841841) PLoS One. 2011 Mar 03;6(3):e14741. (PMID: 21390226) Eur Cytokine Netw. 2008 Mar;19(1):30-6. (PMID: 18299268) Exp Parasitol. 2009 May;122(1):37-40. (PMID: 19545527) J Infect Dis. 2002 Mar 15;185(6):812-9. (PMID: 11920299) Nat Med. 1998 Mar;4(3):358-60. (PMID: 9500614) J Immunol. 2007 Nov 1;179(9):5886-96. (PMID: 17947662) Am J Trop Med Hyg. 2003 Jul;69(1):31-5. (PMID: 12932093) Nature. 2002 Oct 3;419(6906):498-511. (PMID: 12368864) Infect Immun. 2006 Jul;74(7):3904-11. (PMID: 16790763) J Infect Dis. 2002 Jun 1;185(11):1688-91. (PMID: 12023781) Int J Parasitol. 2004 Jul;34(8):935-42. (PMID: 15217732) J Exp Med. 2004 May 3;199(9):1179-90. (PMID: 15123742) Malar J. 2009 Dec 10;8:286. (PMID: 20003246) Malar J. 2002 Apr 26;1:7. (PMID: 12057026) Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1791-800. (PMID: 22619319) PLoS Pathog. 2010 Feb 19;6(2):e1000770. (PMID: 20174609) Infect Immun. 1991 Apr;59(4):1319-24. (PMID: 2004813) J Infect Dis. 2005 Jun 1;191(11):1932-9. (PMID: 15871128) Mol Microbiol. 2008 Jun;68(6):1519-34. (PMID: 18433451) Nat Immunol. 2008 Jul;9(7):725-32. (PMID: 18563083) Infect Immun. 1999 Feb;67(2):733-9. (PMID: 9916084) J Immunol. 1997 Oct 15;159(8):3757-66. (PMID: 9378962) Proc Natl Acad Sci U S A. 1990 Jul;87(14):5484-8. (PMID: 2115172) PLoS Clin Trials. 2006 Oct 20;1(6):e29. (PMID: 17053830) J Leukoc Biol. 2010 Dec;88(6):1131-43. (PMID: 20610802) Annu Rev Microbiol. 2001;55:673-707. (PMID: 11544371) Malar J. 2003 Sep 10;2:27. (PMID: 14565852) Clin Exp Immunol. 1990 Jan;79(1):95-9. (PMID: 1967995) Acta Trop. 2007 Mar;101(3):258-65. (PMID: 17379175) PLoS One. 2013 Aug 14;8(8):e73360. (PMID: 23967342) Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21801-6. (PMID: 20018734) Sci Transl Med. 2012 Apr 11;4(129):129ra45. (PMID: 22496547) PLoS Pathog. 2011 Dec;7(12):e1002389. (PMID: 22144890) |
معلومات مُعتمدة: | 084535 United Kingdom WT_ Wellcome Trust; 084538 United Kingdom WT_ Wellcome Trust; United Kingdom Wellcome Trust; 079082 United Kingdom Wellcome Trust; 077176 United Kingdom WT_ Wellcome Trust; 092654 United Kingdom Wellcome Trust |
فهرسة مساهمة: | Indexing Agency: NLM Local ID #: EMS56059. |
سلسلة جزيئية: | GENBANK HE863905; HE863906; HE863907; HE863908; HE863909; HE863910; HE863911; HE863912; HE863913; HE863914; HE863915; HE863916; HE863917; HE863918; HE863919; HE863920; HE863921; HE863922; HE863923; HE863924; HE863925; HE863926; HE863927; HE863928; HE863929; HE863930; HE863931; HE863932; HE863933; HE863934; HE863935; HE863936; HE863937; HE863938; HE863939; HE863940 |
المشرفين على المادة: | 0 (Antibodies, Protozoan) 0 (Antigens, Protozoan) 0 (IL4 protein, human) 0 (Protozoan Proteins) 0 (erythrocyte membrane protein 1, Plasmodium falciparum) 207137-56-2 (Interleukin-4) 82115-62-6 (Interferon-gamma) |
تواريخ الأحداث: | Date Created: 20140124 Date Completed: 20140414 Latest Revision: 20211021 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3918862 |
DOI: | 10.4049/jimmunol.1200547 |
PMID: | 24453249 |
قاعدة البيانات: | MEDLINE |
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